FUT2 transfers Fuc to LeX to form LeY

Stable Identifier
R-HSA-9603983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The FUT2 gene (originally named the Se gene) expresses galactoside 2-alpha-L-fucosyltransferase 2 present on the Golgi membrane. FUT2 catalyses the α1,2 addition of fucose (Fuc) to Type 1 and Type 2 oligosaccharide chains, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the terminal galactose (Gal) of the Lewis X antigen (LeX) in an α1,2 linkage forms the Lewis Y antigen (LeY) (Kelly et al. 1995, Koda et al. 1997).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
galactoside 2-alpha-L-fucosyltransferase activity of FUT2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created