Activated NTRK3 binds IRS1

Stable Identifier
R-HSA-9603437
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Activated NTRK3 binds IRS1
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Activated wild-type NTRK3 (TRKC), as well as constitutively active ETV6-NTRK3 oncogene, a product of translocation between ETV6 and NTRK3 gene loci in congenital fibrosarcoma and cellular mesoblastic nephroma, are able to bind to adaptor protein IRS1 (Morrison et al. 2002, Lannon et al. 2004, Jin et al. 2008). Binding of IRS1 to NTRK3 is enhanced in the presence of SRC (Jin et al. 2008).

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Activated Ntrk3 binds Irs1 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-21)