Activated NTRK3 promotes SRC autophosphorylation

Stable Identifier
R-HSA-9603420
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Activated NTRK3 promotes SRC autophosphorylation
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Binding of SRC to activated NTRK3 (TRKC) promotes activating SRC autophosphorylation (Jin et al. 2008).
Literature References
PubMed ID Title Journal Year
17991742 c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway

Park, Y, Jin, W, Lee, HD, Yun, C, Jeong, J, Kim, SJ

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane]

Physical Entity
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)
Activated NTRK3 promotes SRC autophosphorylation (Canis familiaris)
Activated NTRK3 promotes SRC autophosphorylation (Gallus gallus)
Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)
Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)
Activated NTRK3 promotes SRC autophosphorylation (Sus scrofa)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-21)
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