Activated NTRK3 promotes SRC autophosphorylation

Stable Identifier
R-HSA-9603420
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated NTRK3 promotes SRC autophosphorylation
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of SRC to activated NTRK3 (TRKC) promotes activating SRC autophosphorylation (Jin et al. 2008).

Literature References
PubMed ID Title Journal Year
17991742 c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway

Jin, W, Yun, C, Jeong, J, Park, Y, Lee, HD, Kim, SJ

J. Biol. Chem. 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane]
Physical Entity
NTF3:p-5Y-NTKR3 homodimer:MyrG-SRC [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activated NTRK3 promotes SRC autophosphorylation (Bos taurus)
Activated NTRK3 promotes SRC autophosphorylation (Danio rerio)
Activated NTRK3 promotes SRC autophosphorylation (Mus musculus)
Activated NTRK3 promotes SRC autophosphorylation (Rattus norvegicus)
Activated NTRK3 promotes SRC autophosphorylation (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-03-21)
Cite Us!