Reactome | Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi

Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi

Stable Identifier

R-HSA-947991

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum quality control compartment, Golgi lumen

ReviewStatus

5/5

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Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi

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The LMAN1(also known as ERGIC-53)/MCFD2 complex recognizes Man8 and Man9 N-glycans released by the Calnexin/Calreticulin cycle and mediate their transport to the Golgi (Nyefeler B et al, 2003; Zhang B et al, 2003). Man8 glycan transfer is shown here.

Literature References

PubMed ID	Title	Journal	Year
12727195	The cargo receptor ERGIC-53 is a target of the unfolded protein response Hauri, HP, Mori, K, Nufer, O, Matsui, T, Nyfeler, B	Biochem Biophys Res Commun	2003
12717434	Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex Ruiz-Saez, A, Cunningham, MA, Pipe, SW, Kaufman, RJ, McVey, JH, Nichols, WC, Schulte-Overberg, U, Bernat, JA, de Bosch, NB, Zhang, B, Tuddenham, EG, Ginsburg, D, Seligsohn, U, White, GC	Nat Genet	2003