Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
UBA6 [cytosol]
Stable Identifier
R-HSA-947701
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin-like modifier-activating enzyme 6, UBA6_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q53GL0 PKHO1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
UBA6 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21816346
Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins
Gygi, SP
,
Sowa, ME
,
Harper, JW
,
Lee, PC
Mol. Cell
2011
External Reference Information
External Reference
UniProt:A0AVT1 UBA6
Gene Names
UBA6, MOP4, UBE1L2
Chain
chain:1-1052
Reference Genes
BioGPS Gene:55236 UBA6
COSMIC (genes):UBA6 UBA6
CTD Gene:55236 UBA6
dbSNP Gene:55236 UBA6
ENSEMBL:ENSG00000033178 UBA6
ENSEMBL_homo_sapiens_GENE:ENSG00000033178.13 UBA6
HGNC:25581 UBA6
KEGG Gene (Homo sapiens):55236 UBA6
Monarch:55236 UBA6
NCBI Gene:55236 UBA6
OMIM:611361 UBA6
UCSC:A0AVT1 UBA6
Reference Transcript
RefSeq:NM_018227.5 UBA6
Other Identifiers
11730893_a_at
11730894_a_at
11730895_at
11762649_at
1555441_PM_at
1555441_at
16976390
218340_PM_s_at
218340_s_at
222600_PM_s_at
222600_s_at
222601_PM_at
222601_at
222602_PM_at
222602_at
242834_PM_at
242834_at
2771725
2771726
2771727
2771728
2771729
2771730
2771731
2771732
2771733
2771734
2771735
2771736
2771737
2771739
2771740
2771742
2771746
2771747
2771748
2771749
2771750
2771752
2771754
2771755
2771756
2771757
2771758
2771759
2771761
2771762
2771763
2771764
2771766
2771771
2771772
2771773
2771776
2771778
2771779
2771781
2771782
2771784
2771786
2771787
2771788
2771790
2771792
2771795
2771798
2771799
47952_at
53204_at
55236
60583_at
75265_at
8100615
86971_at
88384_at
A_23_P218905
A_24_P166144
A_33_P3412035
GE55867
GE582612
GE668766
GE890311
GO:0000166
GO:0003824
GO:0004792
GO:0004839
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0006511
GO:0007612
GO:0007626
GO:0008641
GO:0016567
GO:0016740
GO:0016779
GO:0016874
GO:0019780
GO:0021764
GO:0021766
GO:0030154
GO:0030163
GO:0032446
GO:0036211
GO:0048856
GO:0050877
GO:0060996
GO:0140096
GO:0140657
HMNXSV003021348
Hs.48689.0.A1_3p_at
Hs.59838.0.S1_3p_a_at
Hs.59838.0.S3_3p_at
Hs.59838.0.S4_3p_at
Hs2.59838.2.S1_3p_at
ILMN_1675085
PH_hs_0003410
PH_hs_0003840
TC04001250.hg
TC04002575.hg
g8922683_3p_a_at
Participates
as a component of
Ub-Cys625-UBA6 [cytosol] (Homo sapiens)
UBA6:ubiquitin adenylate [cytosol] (Homo sapiens)
as an input of
UBA6 adenylates ubiquitin in the cytosol (Homo sapiens)
as a candidate of
Ubiquitin activating E1 enzymes [cytosol] (Homo sapiens)
Inferred To
Homologues of UBA6 [cytosol]
(Plasmodium falciparum)
uba6 [cytosol]
(Xenopus tropicalis)
UBA6 [cytosol]
(Bos taurus)
UBA6 [cytosol]
(Canis familiaris)
UBA6 [cytosol]
(Dictyostelium discoideum)
UBA6 [cytosol]
(Gallus gallus)
UBA6 [cytosol]
(Mus musculus)
UBA6 [cytosol]
(Plasmodium falciparum)
UBA6 [cytosol]
(Sus scrofa)
Uba6 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_060697.4
OpenTargets
ENSG00000033178
HPA
ENSG00000033178-UBA6
GeneCards
A0AVT1
ZINC - Substances
UBA6_HUMAN
ZINC target
A0AVT1
Ensembl
ENSG00000033178
,
ENST00000322244
,
ENSP00000399234
,
ENSP00000313454
,
ENST00000420827
PRO
A0AVT1
Pharos - Targets
A0AVT1
ZINC - Predictions - Purchasable
UBA6_HUMAN
PDB
7SOL
,
7PVN
,
7PYV
HMDB Protein
HMDBP09292
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6NT76 HMBX1
0.556
3
UniProt:Q9Y6Q1 CAPN6
1
CAPN6 [cytosol]
(R-HSA-8848635)
0.527
2
UniProt:Q96QD9 FYTTD1
1
FYTTD1 [nucleoplasm]
(R-HSA-8852176)
0.527
2
UniProt:O95221 OR5F1
1
OR5F1 [endoplasmic reticulum membrane]
(R-HSA-9751480)
0.527
2
UniProt:Q53GL0 PKHO1
0.527
2
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.527
2
UniProt:P43353 ALDH3B1
3
ALDH3B1 [plasma membrane]
(R-HSA-5696096)
ALDH3B1 [secretory granule membrane]
(R-HSA-6801023)
ALDH3B1 [specific granule membrane]
(R-HSA-6799510)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text