Reactome | BRS3 [plasma membrane]

BRS3 [plasma membrane]

Stable Identifier

R-HSA-947694

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Bombesin receptor subtype-3, BRS3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Bombesin-like receptors bind bombesin homologues (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor:bombesin-like peptide [plasma membrane] (Homo sapiens)
        
        Bombesin-like receptor [plasma membrane] (Homo sapiens)
        
        BRS3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32247 BRS3

Gene Names

BRS3

Chain

chain:1-399

Reference Genes

BioGPS Gene:680 BRS3

COSMIC (genes):BRS3 BRS3

CTD Gene:680 BRS3

dbSNP Gene:680 BRS3

ENSEMBL:ENSG00000102239 BRS3

HGNC:1113 BRS3

KEGG:hsa:680 BRS3

Monarch:680 BRS3

NCBI Gene:680 BRS3

OMIM:300107 BRS3

UCSC:P32247 BRS3

Reference Transcript

RefSeq:NM_001727.1 BRS3

Other Identifiers

11737304_at

1552818_PM_a_at

1552818_a_at

17107287

207369_PM_at

207369_at

35128_at

3992511

3992513

3992514

3992515

3992516

3992518

3992519

3992520

680

8170159

A_23_P33961

GE687749

GE80634

GO:0004930

GO:0004946

GO:0005886

GO:0005975

GO:0006006

GO:0007186

GO:0007218

GO:0008188

GO:0008217

GO:0008343

GO:0008528

GO:0016020

GO:0031989

GO:0060089

HMNXSV003011899

Hs.121484.0.S2_3p_at

Hs2.121484.1.S1_3p_s_at

ILMN_1756165

PH_hs_0006756

TC0X000660.hg

X76498_at

Participates

as a candidate of

Bombesin-like receptor [plasma membrane] (Homo sapiens)

Inferred To

CCHa1-R [plasma membrane] (Drosophila melanogaster)

Homologues of BRS3 [plasma membrane] (Drosophila melanogaster)

CCHa2-R [plasma membrane] (Drosophila melanogaster)

brs3 [plasma membrane] (Xenopus tropicalis)

BRS3 [plasma membrane] (Bos taurus)

BRS3 [plasma membrane] (Canis familiaris)

BRS3 [plasma membrane] (Sus scrofa)

BRS3.5 [plasma membrane] (Gallus gallus)

Brs3 [plasma membrane] (Mus musculus)

Brs3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001718.1

Guide to Pharmacology - Targets

ENSEMBL

ENST00000370648, ENSP00000359682, ENSG00000102239

OpenTargets

ENSG00000102239

ZINC - Substances

BRS3_HUMAN

ZINC target

P32247

PRO

P32247

GlyGen

P32247

PDB

8Y53, 8Y52

ZINC - Investigational

BRS3_HUMAN

GeneCards

BRS3

HPA

ENSG00000102239-BRS3

Pharos - Targets

P32247

ZINC - Predictions - Purchasable

BRS3_HUMAN

HMDB Protein

HMDBP07474