Reactome | UBE2H [cytosol]

UBE2H [cytosol]

Stable Identifier

R-HSA-947638

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin-conjugating enzyme E2 H, UBE2H_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
        
        E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
        
        UBE2H [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62256 UBE2H

Gene Names

UBE2H

Chain

chain:1-183

Reference Genes

BioGPS Gene:7328 UBE2H

COSMIC (genes):UBE2H UBE2H

CTD Gene:7328 A4D1L5

dbSNP Gene:7328 UBE2H

ENSEMBL:ENSG00000186591 UBE2H

HGNC:12484 UBE2H

KEGG:hsa:7328 UBE2H

Monarch:7328 UBE2H

NCBI Gene:7328 UBE2H

OMIM:601082 UBE2H

UCSC:P62256 UBE2H

Reference Transcript

Other Identifiers

11728669_a_at

11728670_a_at

11728671_s_at

11728672_x_at

11758999_s_at

17062811

217799_PM_x_at

217799_x_at

221962_PM_s_at

221962_s_at

222419_PM_x_at

222419_x_at

222420_PM_s_at

222420_s_at

222421_PM_at

222421_at

3072273

3072275

3072277

3072278

3072279

3072280

3072281

3072282

3072283

3072289

3072290

3072291

3072299

3072300

3072301

3072302

3072305

3072311

3072312

3072313

3072335

3072339

3072341

3072342

3072343

3104931

3104932

369_s_at

7328

8142886

91147_at

A_19_P00809860

A_23_P145584

A_23_P215096

A_33_P3341234

GE60387

GE61572

GE657548

GE85317

GE86420

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005829

GO:0006511

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0032446

GO:0043161

GO:0043226

GO:0061631

GO:0070936

GO:0070979

GO:0140096

HMNXSV003022980

Hs.28505.0.S1_3p_at

Hs.28505.0.S3_3p_a_at

Hs.28505.0.S4_3p_at

Hs.28505.2.S1_3p_s_at

ILMN_1674633

ILMN_1757644

PH_hs_0018037

TC07001858.hg

TC07003166.hg

Z29331_at

g4507782_3p_a_at

p33829

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Homo sapiens)

as a candidate of

E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)

Other forms of this molecule

Ub-C87-UBE2H [cytosol]

Inferred To

ubc8 [cytosol] (Schizosaccharomyces pombe)

ube2h [cytosol] (Danio rerio)

ube2h [cytosol] (Xenopus tropicalis)

UBC8 [cytosol] (Saccharomyces cerevisiae)

UbcE2H [cytosol] (Drosophila melanogaster)

Ube2h [cytosol] (Mus musculus)

Ube2h [cytosol] (Rattus norvegicus)

ubc-8 [cytosol] (Caenorhabditis elegans)

UBE2H [cytosol] (Bos taurus)

UBE2H [cytosol] (Canis familiaris)

UBE2H [cytosol] (Dictyostelium discoideum)

UBE2H [cytosol] (Gallus gallus)

UBE2H [cytosol] (Plasmodium falciparum)

UBE2H [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000473814, ENSG00000186591, ENSP00000347836, ENSP00000419097, ENST00000355621

OpenTargets

ENSG00000186591

IntEnz

2.3.2.24

GeneCards

UBE2H

HPA

ENSG00000186591-UBE2H

PRO

P62256

Pharos - Targets

P62256

HMDB Protein

HMDBP11992

PDB

8PJN, 2Z5D

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2