Reactome | Exchange of oxygen with sulfur in MoCo

Exchange of oxygen with sulfur in MoCo

Stable Identifier

R-HSA-947499

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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While the biosynthesis of the molybdenum cofactor for sulfite oxidase is finished after molybdenum ion insertion, human xanthine oxidase and aldehyde oxidase will only show activity with this cofactor when one of the oxygens bound to molybdenum is replaced with sulfur. The exchange is catalyzed by the MOCOS cysteine desulfurase (Ichida et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
11302742	Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II Nishino, T, Sakuma, R, Matsumura, T, Ichida, K, Hosoya, T	Biochem Biophys Res Commun	2001