Reactome | OAS1 [cytosol]

OAS1 [cytosol]

Stable Identifier

R-HSA-947486

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2'-5'-oligoadenylate synthase 1, OAS1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P00973 OAS1

Gene Names

OAS1, OIAS

Chain

chain:1-400

Reference Genes

BioGPS Gene:4938 OAS1

COSMIC (genes):OAS1 OAS1

CTD Gene:4938 OAS1

dbSNP Gene:4938 OAS1

ENSEMBL:ENSG00000089127 OAS1

HGNC:8086 OAS1

KEGG:hsa:4938 OAS1

Monarch:4938 OAS1

NCBI Gene:4938 OAS1

OMIM:164350 OAS1

UCSC:P00973 OAS1

Reference Transcript

Participates

as an input of

OAS1 binds viral dsRNA (Homo sapiens)

as a component of

OAS1:OAS1 ligand [cytosol] (Homo sapiens)

as a member of

OAS proteins [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001307080.1, NP_058132.2, NP_002525.2, NP_001027581.1

ENSEMBL

ENSP00000388001, ENSP00000505572, ENST00000681934, ENSG00000089127, ENST00000202917, ENSP00000505482, ENSP00000202917, ENST00000452357, ENSP00000415721, ENST00000445409, ENST00000680189, ENST00000551241, ENSP00000448790

OpenTargets

ENSG00000089127

GeneCards

OAS1

HPA

ENSG00000089127-OAS1

PRO

P00973

Pharos - Targets

P00973

Orphanet

OAS1

PDB

4IG8

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.666	5
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722) ACTN1 [cytosol] (R-HSA-354096)	0.666	4
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2

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