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OAS1 [cytosol]
Stable Identifier
R-HSA-947486
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
2'-5'-oligoadenylate synthase 1, OAS1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
OAS antiviral response (Homo sapiens)
OAS1 binds viral dsRNA (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
OAS1:OAS1 ligand [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
OAS1 oligomerizes (Homo sapiens)
OAS1 tetramer:OAS1 ligand [cytosol] (Homo sapiens)
OAS1:OAS1 ligand [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
OAS1:OAS1 ligand [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
OAS1 produces oligoadenylates (Homo sapiens)
OAS1 tetramer:OAS1 ligand [cytosol] (Homo sapiens)
OAS1:OAS1 ligand [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
OAS proteins [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
OAS proteins [cytosol] (Homo sapiens)
OAS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00973 OAS1
Gene Names
OAS1, OIAS
Chain
chain:1-400
Reference Genes
BioGPS Gene:4938 OAS1
COSMIC (genes):OAS1 OAS1
CTD Gene:4938 OAS1
dbSNP Gene:4938 OAS1
ENSEMBL:ENSG00000089127 OAS1
ENSEMBL:ENSG00000089127.15 OAS1
HGNC:8086 OAS1
KEGG Gene (Homo sapiens):4938 OAS1
Monarch:4938 OAS1
NCBI Gene:4938 OAS1
OMIM:164350 OAS1
UCSC:P00973 OAS1
Reference Transcript
RefSeq:NM_001320151.1 OAS1
RefSeq:NM_002534.3 OAS1
RefSeq:NM_016816.3 OAS1
RefSeq:NM_001032409.2 OAS1
Other Identifiers
11719588_a_at
11724255_a_at
11724256_s_at
11740891_a_at
16757324
202869_PM_at
202869_at
205552_PM_s_at
205552_s_at
3432439
3432440
3432442
3432443
3432446
3432447
3432448
3432451
3432452
3432455
3432456
3432457
3432458
3432459
3432460
3432461
3432462
3432463
3432464
3432466
38388_at
38389_at
4938
7958884
A_14_P111276
A_23_P64828
GE58738
GO:0000166
GO:0001730
GO:0002376
GO:0003723
GO:0003725
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0005840
GO:0005975
GO:0006006
GO:0006091
GO:0009615
GO:0016020
GO:0016740
GO:0016779
GO:0023052
GO:0032728
GO:0032760
GO:0034138
GO:0034142
GO:0035457
GO:0035458
GO:0042593
GO:0042742
GO:0043129
GO:0043226
GO:0043231
GO:0045071
GO:0045087
GO:0046872
GO:0051259
GO:0051607
GO:0060337
GO:0060339
GO:0060700
GO:0065003
GO:0070106
GO:0071639
GO:0071659
GO:0098542
GO:0098586
GO:0140374
GO:1901857
GO:2000342
HMNXSV003037423
HMNXSV003044512
ILMN_1658247
ILMN_1672606
ILMN_1675640
ILMN_2410826
PH_hs_0025871
PH_hs_0033487
TC12000884.hg
TC12002572.hg
X02874_at
X02875_s_at
g8051620_3p_at
g8051622_3p_a_at
g8051622_3p_at
g8051622_3p_x_at
Participates
as an input of
OAS1 binds viral dsRNA (Homo sapiens)
as a component of
OAS1:OAS1 ligand [cytosol] (Homo sapiens)
as a member of
OAS proteins [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001027581.1
,
NP_058132.2
,
NP_001307080.1
,
NP_002525.2
OpenTargets
ENSG00000089127
HPA
ENSG00000089127-OAS1
GeneCards
P00973
Ensembl
ENST00000452357
,
ENSP00000202917
,
ENSP00000415721
,
ENSP00000448790
,
ENSG00000089127
,
ENST00000680189
,
ENST00000551241
,
ENSP00000388001
,
ENST00000445409
,
ENSP00000505482
,
ENSP00000505572
,
ENST00000681934
,
ENST00000202917
PRO
P00973
Pharos - Targets
P00973
Orphanet
27131
PDB
4IG8
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.666
4
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.666
5
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.556
3
UniProt:Q96LA8 PRMT6
1
PRMT6 [nucleoplasm]
(R-HSA-5226884)
0.508
2
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