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PXLP-K405-GAD1 [plasma membrane]
Stable Identifier
R-HSA-947477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glutamate decarboxylase 1, DCE1_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
PXLP-GAD dimers [plasma membrane] (Homo sapiens)
PXLP-GAD1:PXLP-GAD2 [plasma membrane] (Homo sapiens)
PXLP-K405-GAD1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99259 GAD1
Gene Names
GAD1, GAD, GAD67
Chain
chain:1-594
Reference Genes
BioGPS Gene:2571 GAD1
COSMIC (genes):GAD1 GAD1
CTD Gene:2571 GAD1
dbSNP Gene:2571 GAD1
ENSEMBL:ENSG00000128683.14 GAD1
HGNC:4092 GAD1
KEGG Gene (Homo sapiens):2571 GAD1
Monarch:2571 GAD1
NCBI Gene:2571 GAD1
OMIM:605363 GAD1
UCSC:Q99259 GAD1
Reference Transcript
RefSeq:XM_017003756.1 GAD1
RefSeq:NM_013445.3 GAD1
RefSeq:XM_011510922.1 GAD1
RefSeq:NM_000817.2 GAD1
RefSeq:XM_005246444.2 GAD1
RefSeq:XM_017003758.1 GAD1
Other Identifiers
0000130022
0000130433
0000130494
11725618_a_at
11725619_a_at
11729094_a_at
16887492
205278_PM_at
205278_at
206669_PM_at
206669_at
206670_PM_s_at
206670_s_at
2514973
2514974
2514975
2514976
2514977
2514978
2514979
2514980
2514981
2514982
2514983
2514984
2514989
2515001
2515003
2515013
2515019
2515020
2515021
2515023
2515027
2515029
2515030
2515033
2515035
2515036
2515038
2515043
2515044
2515045
2515046
2515047
2515048
2515049
2571
37183_at
8046283
84447_at
A_14_P101836
A_23_P209578
A_23_P374689
A_24_P319711
A_33_P3365142
GE58098
GO:0003824
GO:0004351
GO:0005515
GO:0005622
GO:0005737
GO:0005886
GO:0005938
GO:0006520
GO:0006538
GO:0006540
GO:0007268
GO:0009449
GO:0012506
GO:0016829
GO:0016830
GO:0016831
GO:0018352
GO:0019752
GO:0023052
GO:0030170
GO:0030424
GO:0031410
GO:0035176
GO:0035641
GO:0036211
GO:0042136
GO:0042802
GO:0043226
GO:0043679
GO:0044306
GO:0045202
GO:0048786
GO:0060077
GO:0061202
HMNXSV003026699
HMNXSV003031564
HMNXSV003056403
ILMN_1660973
ILMN_1712731
ILMN_1812859
ILMN_2292646
M81883_at
PH_hs_0025119
TC02001016.hg
g4503872_3p_at
g7305076_3p_a_at
g7305076_3p_at
Participates
as a component of
PXLP-GAD1:PXLP-GAD2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PXLP-K405-GAD1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Inferred To
PXLP-K405-GAD1 [plasma membrane]
(Bos taurus)
PXLP-K405-GAD1 [plasma membrane]
(Danio rerio)
PXLP-K405-GAD1 [plasma membrane]
(Drosophila melanogaster)
PXLP-K405-GAD1 [plasma membrane]
(Mus musculus)
PXLP-K405-GAD1 [plasma membrane]
(Rattus norvegicus)
PXLP-K405-GAD1 [plasma membrane]
(Sus scrofa)
GAD1 [plasma membrane]
(Sus scrofa)
unc-25 [plasma membrane]
(Caenorhabditis elegans)
Homologues of PXLP-K405-GAD1 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 405
Coordinate
405
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
XP_005246501.1
,
XP_016859245.1
,
XP_011509224.1
,
NP_038473.2
,
NP_000808.2
,
XP_016859247.1
Guide to Pharmacology - Targets
1272
OpenTargets
ENSG00000128683
HPA
ENSG00000128683-GAD1
GeneCards
Q99259
Ensembl
ENSP00000364421
,
ENSP00000486612
,
ENSP00000341167
,
ENST00000625689
,
ENSG00000128683
,
ENST00000344257
,
ENSP00000434696
,
ENSP00000350928
,
ENST00000375272
,
ENST00000358196
,
ENST00000493875
PRO
Q99259
Pharos - Targets
Q99259
Orphanet
20284
HMDB Protein
HMDBP00703
PDB
2OKJ
,
3VP6
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46952 HAAO
1
HAAO [cytosol]
(R-HSA-71085)
0.83
8
UniProt:Q96DZ9-2 CMTM5
0.718
6
UniProt:Q969L2 MAL2
0.718
6
UniProt:Q6RW13-2 AGTRAP
0.718
6
UniProt:Q96DZ9 CKLF5
0.666
4
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
0.556
3
UniProt:P38635 HIS9
0.556
3
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
STK3(1-491) [cytosol]
(R-HSA-2028280)
0.556
3
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