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RGS12 [plasma membrane]
Stable Identifier
R-HSA-939784
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 12, RGS12_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS12 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14924 RGS12
Gene Names
RGS12
Chain
chain:1-1447
Reference Genes
BioGPS Gene:6002 RGS12
COSMIC (genes):RGS12 RGS12
CTD Gene:6002 RGS12
dbSNP Gene:6002 RGS12
ENSEMBL:ENSG00000159788 RGS12
HGNC:9994 RGS12
KEGG:hsa:6002 RGS12
Monarch:6002 RGS12
NCBI Gene:6002 RGS12
OMIM:602512 RGS12
UCSC:O14924 RGS12
Reference Transcript
RefSeq:NM_198227.1 RGS12
RefSeq:XM_006713907.1 RGS12
RefSeq:XM_011513543.2 RGS12
RefSeq:XM_017008529.1 RGS12
RefSeq:NM_002926.3 RGS12
RefSeq:XM_006713905.1 RGS12
RefSeq:XM_017008533.1 RGS12
RefSeq:XM_006713906.2 RGS12
RefSeq:NM_198229.2 RGS12
RefSeq:XM_017008532.1 RGS12
RefSeq:XM_017008531.1 RGS12
Other Identifiers
11722649_at
11722650_s_at
11735762_s_at
11746276_s_at
11746277_s_at
11746541_a_at
11748658_a_at
11760589_a_at
11762003_at
11763779_a_at
1555022_PM_at
1555022_at
1555032_PM_at
1555032_at
1555033_PM_a_at
1555033_a_at
16964415
205823_PM_at
205823_at
209637_PM_s_at
209637_s_at
209639_3p_s_at
209639_PM_s_at
209639_s_at
214361_PM_s_at
214361_s_at
214362_PM_at
214362_at
242079_PM_at
242079_at
2716026
2716031
2716032
2716033
2716034
2716035
2716041
2716042
2716043
2716044
2716045
2716048
2716049
2716051
2716052
2716053
2716054
2716055
2716056
2716057
2716063
2716068
2716069
2716070
2716071
2716072
2716073
2716074
2716075
2716076
2716077
2716078
2716079
2716080
2716081
2716082
2716083
2716084
2716085
2716086
2716087
2716088
2716089
2716091
2716092
2716093
2716094
2716095
2716097
2716098
2716099
2716100
2716101
2716103
2716104
2716105
2716106
2716107
2716108
2716109
2716110
2716111
2716112
2716113
2716114
2716115
2716118
2716119
2716120
2716121
2716123
32580_at
37404_at
44320_at
47498_at
6002
8093764
A_23_P352435
A_23_P69513
A_24_P220786
A_24_P33705
GE54230
GO:0000228
GO:0000794
GO:0003824
GO:0003924
GO:0005096
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007186
GO:0008277
GO:0009968
GO:0016363
GO:0016787
GO:0030425
GO:0030695
GO:0042995
GO:0043226
GO:0045202
GO:0098772
HMNXSV003013537
HMNXSV003026419
HMNXSV003053753
Hs.194461.0.A1_3p_at
Hs.78281.0.S2_3p_at
Hs.78281.3.A1_3p_a_at
Hs.78281.4.S1_3p_a_at
Hs2.78281.5.S1_3p_at
Hs2.78281.6.S1_3p_at
ILMN_1692688
ILMN_1713219
ILMN_1722834
ILMN_1751141
ILMN_1791314
ILMN_2384629
PH_hs_0025360
TC04001863.hg
g2599396_3p_a_at
Participates
as a member of
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
as a candidate of
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
Inferred To
Rgs12 [plasma membrane]
(Mus musculus)
Rgs12 [plasma membrane]
(Rattus norvegicus)
loco [plasma membrane]
(Drosophila melanogaster)
RGS12 [plasma membrane]
(Canis familiaris)
RGS12 [plasma membrane]
(Gallus gallus)
RGS12 [plasma membrane]
(Sus scrofa)
rgs12b [plasma membrane]
(Danio rerio)
Cross References
Guide to Pharmacology - Targets
2819
ENSEMBL
ENST00000344733
,
ENST00000382788
,
ENSP00000342133
,
ENSP00000339381
,
ENSP00000372238
,
ENST00000338806
,
ENSG00000159788
,
ENSP00000338509
,
ENST00000336727
OpenTargets
ENSG00000159788
GeneCards
RGS12
HPA
ENSG00000159788-RGS12
PRO
O14924
Pharos - Targets
O14924
PDB
2EBZ
,
2KV8
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.615
4
UniProt:P56559 ARL4C
1
ARL4C [plasma membrane]
(R-HSA-9618406)
0.527
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
3
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