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RGS21 [plasma membrane]
Stable Identifier
R-HSA-939776
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 21, RGS21_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS21 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2M5E4 RGS21
Gene Names
RGS21
Chain
chain:1-152
Reference Genes
BioGPS Gene:431704 RGS21
COSMIC (genes):RGS21 RGS21
CTD Gene:431704 RGS21
dbSNP Gene:431704 RGS21
ENSEMBL:ENSG00000253148 RGS21
HGNC:26839 RGS21
KEGG:hsa:431704 RGS21
Monarch:431704 RGS21
NCBI Gene:431704 RGS21
OMIM:612407 RGS21
UCSC:Q2M5E4 RGS21
Reference Transcript
RefSeq:NM_001039152.3 RGS21
Other Identifiers
11738545_at
16675290
2372759
2372761
2372764
2372765
431704
7908382
A_33_P3388691
GO:0003824
GO:0003924
GO:0005886
GO:0007186
GO:0009968
GO:0016787
GO:0019226
GO:0050877
GO:0050913
GO:0050916
GO:0050917
HMNXSV003037630
TC01001620.hg
Participates
as a member of
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
as a candidate of
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (q) [plasma membrane] (Homo sapiens)
Inferred To
rgs-10 [plasma membrane]
(Caenorhabditis elegans)
rgs-6 [plasma membrane]
(Caenorhabditis elegans)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-3 [plasma membrane]
(Caenorhabditis elegans)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
Rgs21 [plasma membrane]
(Mus musculus)
Rgs21 [plasma membrane]
(Rattus norvegicus)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
si:ch211-152p11.4 [plasma membrane]
(Danio rerio)
rgs-8.1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS21 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS21 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS21 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-11 [plasma membrane]
(Caenorhabditis elegans)
rgs-4 [plasma membrane]
(Caenorhabditis elegans)
rgs-7 [plasma membrane]
(Caenorhabditis elegans)
RGS21 [plasma membrane]
(Bos taurus)
RGS21 [plasma membrane]
(Canis familiaris)
RGS21 [plasma membrane]
(Dictyostelium discoideum)
RGS21 [plasma membrane]
(Gallus gallus)
RGS21 [plasma membrane]
(Sus scrofa)
rgs-9 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
2809
ENSEMBL
ENST00000417209
,
ENSP00000428343
,
ENSG00000253148
OpenTargets
ENSG00000253148
GeneCards
RGS21
HPA
ENSG00000253148-RGS21
PRO
Q2M5E4
Pharos - Targets
Q2M5E4
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