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RGS1 [plasma membrane]
Stable Identifier
R-HSA-939775
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Regulator of G-protein signaling 1, RGS1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (i) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Homo sapiens)
G alpha (i):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (i):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Active G alpha (q) binds RGS proteins (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (q) in G (q):RGS complex is inactivated (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (q):GTP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
G alpha (q):RGS dissociates to inactive G alpha (q) (Homo sapiens)
G alpha (q):GDP:RGS [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08116 RGS1
Gene Names
RGS1, 1R20, BL34, IER1
Chain
chain:1-209
Reference Genes
BioGPS Gene:5996 RGS1
COSMIC (genes):RGS1 RGS1
CTD Gene:5996 RGS1
dbSNP Gene:5996 RGS1
ENSEMBL:ENSG00000090104 RGS1
HGNC:9991 RGS1
KEGG:hsa:5996 RGS1
Monarch:5996 RGS1
NCBI Gene:5996 RGS1
OMIM:600323 RGS1
UCSC:Q08116 RGS1
Reference Transcript
RefSeq:NM_002922.3 RGS1
Other Identifiers
11742765_at
11760967_at
16675301
202988_3p_s_at
202988_PM_s_at
202988_s_at
216834_3p_at
216834_PM_at
216834_at
2372788
2372789
2372790
2372791
2372792
2372793
2372794
2372795
2372796
2372797
2372798
2372799
2372800
2372801
36575_at
5996
7908388
A_14_P123371
A_14_P202511
A_23_P97141
GE62011
GE81210
GO:0001965
GO:0002376
GO:0003824
GO:0003924
GO:0005096
GO:0005516
GO:0005737
GO:0005829
GO:0005886
GO:0006955
GO:0007165
GO:0007186
GO:0007193
GO:0009617
GO:0009898
GO:0009968
GO:0016787
GO:0043547
GO:0061737
GO:0098772
HMNXSV003033892
Hs.75256.1.S1_3p_a_at
Hs.75256.1.S1_3p_at
ILMN_1656011
PH_hs_0004299
S59049_at
TC01001622.hg
g4506514_3p_a_at
Participates
as a member of
RGS1,2,3,4,5,13,16,17,18,19,21 [plasma membrane] (Homo sapiens)
RGS proteins active for G alpha (i) [plasma membrane] (Homo sapiens)
RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21 [plasma membrane] (Homo sapiens)
Inferred To
rgs-10 [plasma membrane]
(Caenorhabditis elegans)
rgs-6 [plasma membrane]
(Caenorhabditis elegans)
Rgs1 [plasma membrane]
(Mus musculus)
Rgs1 [plasma membrane]
(Rattus norvegicus)
SST2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs-3 [plasma membrane]
(Caenorhabditis elegans)
RGS2 [plasma membrane]
(Saccharomyces cerevisiae)
rgs1 [plasma membrane]
(Schizosaccharomyces pombe)
rgs1 [plasma membrane]
(Xenopus tropicalis)
si:ch211-152p11.4 [plasma membrane]
(Danio rerio)
rgs-8.1 [plasma membrane]
(Caenorhabditis elegans)
rgs-11 [plasma membrane]
(Caenorhabditis elegans)
rgs-4 [plasma membrane]
(Caenorhabditis elegans)
rgs-7 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RGS1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RGS1 [plasma membrane]
(Saccharomyces cerevisiae)
RGS1 [plasma membrane]
(Bos taurus)
RGS1 [plasma membrane]
(Canis familiaris)
RGS1 [plasma membrane]
(Dictyostelium discoideum)
RGS1 [plasma membrane]
(Gallus gallus)
RGS1 [plasma membrane]
(Sus scrofa)
rgs-9 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
2804
ENSEMBL
ENSP00000356429
,
ENSP00000464323
,
ENST00000367459
,
ENST00000469578
OpenTargets
ENSG00000090104
HPA
ENSG00000090104-RGS1
PRO
Q08116
Pharos - Targets
Q08116
PDB
2GTP
,
2BV1
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