NLRC5 interacts with DDX58/IFIH1

Stable Identifier
R-HSA-937343
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol
Synonyms
NLRC5 interacts with RIG-I/MDA5 and inhibit IPS-1 binding
ReviewStatus
5/5
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NLRC5 interacts with DDX58/IFIH1
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NLRC5 competes with IPS-1 for binding to the CARD domain of RIG-I/MDA5. NLRC5 specifically recognize the CARD domains of RIG-I/MDA5 when the CARD domains become accessible after viral infection, leading to dampened activation of IRF3.
Literature References
PubMed ID Title Journal Year
20434986 NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

Shen, P, Cui, J, Wang, HY, Hong, J, Wang, RF, Xia, X, Zhu, L, Ji, J, Chen, ZJ, Legras, X, Zheng, S

Cell 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding. (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-26)
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