TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination

Stable Identifier
R-HSA-937337
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
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TAX1BP1 functions as an adaptor molecule for A20 to terminate antiviral signaling. TAX1BP1 and A20 blocked antiviral signaling by disrupting K63-linked polyubiquitination of TBK1-IKKi.

Literature References
PubMed ID Title Journal Year
20304918 TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

Harhaj, EW, Barber, GN, Parvatiyar, K

J Biol Chem 2010
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Orthologous Events
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Bos taurus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Canis familiaris)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Danio rerio)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Gallus gallus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Mus musculus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Rattus norvegicus)
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination (Sus scrofa)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-26)
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