activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane]

Stable Identifier
R-HSA-937070
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
14517278 LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters

Fitzgerald, KA, Rowe, DC, Barnes, BJ, Caffrey, DR, Visintin, A, Latz, E, Monks, BG, Pitha-Rowe, PM, Golenbock, DT

J Exp Med 2003
17823124 Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF

Gatot, JS, Gioia, R, Chau, TL, Patrascu, F, Warnier, M, Close, P, Chapelle, JP, Muraille, E, Brown, K, Siebenlist, U, Piette, J, Dejardin, E, Chariot, A

J. Biol. Chem. 2007
Participants
components
Participant Of
output
input
Inferred To
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Canis familiaris)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Danio rerio)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Gallus gallus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Mus musculus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Rattus norvegicus)
activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKE:IRF3/IRF7 [endosome membrane] (Sus scrofa)
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