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p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
Stable Identifier
R-HSA-937060
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Homo sapiens)
Activated TAK1 phosphorylates MKK4/MKK7 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
activated human TAK1 phosphorylates MKK3/MKK6 (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Ubiquitination of IKBKG by TRAF6 (Homo sapiens)
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Homo sapiens)
Participants
components
x 3
K63polyUb [cytosol]
(Homo sapiens)
p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol]
(Homo sapiens)
x 3
p-T184,T187-MAP3K7 [cytosol]
(Homo sapiens)
Participates
as a member of
K63pUb-TRAF6:TAK1 complexes [cytosol] (Homo sapiens)
Activated TAK complexes [cytosol] (Homo sapiens)
Inferred To
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Bos taurus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Canis familiaris)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Drosophila melanogaster)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Gallus gallus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Mus musculus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Rattus norvegicus)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Sus scrofa)
p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(Xenopus tropicalis)
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