Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex

Stable Identifier
R-HSA-937059
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
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IRAK4 deficient macrophages fail to induce IRAK2 phosphorylation (Kawagoe et al. 2008), suggesting that activated IRAK4 phosphorylates IRAK2 as it does IRAK1.

Phosphorylation sites of IRAK2 remain to be characterized.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kawagoe, T, Sato, S, Matsushita, K, Kato, H, Matsui, K, Kumagai, Y, Saitoh, T, Kawai, T, Takeuchi, O, Akira, S

Nat Immunol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK2:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created