Reactome | TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]

Stable Identifier

R-HSA-937038

Type

Complex

Species

Homo sapiens

Compartment

cytosol

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Literature References

PubMed ID	Title	Journal	Year
21220427	Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression Piao, W, Qiu, F, Xiong, Y, Medvedev, AE, Wahl, LM, Song, C	J. Biol. Chem.	2011
18347055	Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation Conze, DB, Landstrom, A, Ashwell, JD, Thomas, JA, Wu, CJ	Mol Cell Biol	2008

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