Reactome | IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP

IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP

Stable Identifier

R-HSA-937022

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Chlamydia trachomatis, Neisseria meningitidis serogroup B

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP

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IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.

Literature References

PubMed ID	Title	Journal	Year
17485511	Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling Takeuchi, O, Yamamoto, M, Sato, S, Jung, A, Akira, S, Matsui, K, Kato, H, Uematsu, S, Kawagoe, T	J Exp Med	2007
17141195	Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop Dahlstrand, E, Wang, A, Ocain, TD, Li, Z, Addona, T, Xu, Y, Lu, C, Dorsch, M, Keshishian, H, Parsons, TF, Li, P, Jaffee, B, Cheng, H	Biochem Biophys Res Commun	2007