IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP

Stable Identifier
R-HSA-937022
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
cytosol, plasma membrane
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IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
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IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.

Literature References
PubMed ID Title Journal Year
17141195 Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

Cheng, H, Addona, T, Keshishian, H, Dahlstrand, E, Lu, C, Dorsch, M, Li, Z, Wang, A, Ocain, TD, Li, P, Parsons, TF, Jaffee, B, Xu, Y

Biochem Biophys Res Commun 2007
17485511 Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

Kawagoe, T, Sato, S, Jung, A, Yamamoto, M, Matsui, K, Kato, H, Uematsu, S, Takeuchi, O, Akira, S

J Exp Med 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
Physical Entity
IRAK4:oligo-MyD88:TIRAP:activated TLR [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Autophosphorylation of chicken IRAK4 (Gallus gallus)
Authored
Shamovsky, V  (2010-06-01)
Reviewed
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
Shamovsky, V  (2010-08-25)