activated TLR4:TRIF:K63polyUb-TRAF3:K63polyUb-TANK:p-TBK1/p-IKKi [endosome membrane]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
17823124 Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF

Gatot, JS, Gioia, R, Chau, TL, Patrascu, F, Warnier, M, Close, P, Chapelle, JP, Muraille, E, Brown, K, Siebenlist, U, Piette, J, Dejardin, E, Chariot, A

J. Biol. Chem. 2007
19656901 Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling

Piao, W, Song, C, Chen, H, Diaz, MA, Wahl, LM, Fitzgerald, KA, Li, L, Medvedev, AE

J. Leukoc. Biol. 2009
14530355 Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling

Sato, S, Sugiyama, M, Yamamoto, M, Watanabe, Y, Kawai, T, Takeda, K, Akira, S

J. Immunol. 2003
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