Reactome | NLRX1 inhibits MAVS-DDX58 interaction

NLRX1 inhibits MAVS-DDX58 interaction

Stable Identifier

R-HSA-936564

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

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NLRX1 is a member of nucleotide-binding domain and leucine-rich repeat containing (NLR) protein family. NLRX1 competes with RIG-I for IPS-1 interaction and has been identified as a negative regulator of RLR signaling. NLRX1 resides at the outer mitochondrial membrane where IPS-1 is located and this interaction is mediated by the CARD region of IPS-1 and a putative nucleotide-binding domain (NBD) of NLRX1. This interaction between NLRX1 and IPS-1 prevents the association between RIG-1/MDA5 and IPS-1.

Literature References

PubMed ID	Title	Journal	Year
18200010	NLRX1 is a regulator of mitochondrial antiviral immunity Ting, JP, Duncan, JA, Lei, Y, Heise, MT, Lich, JD, Sun, L, Chen, Z, Ye, Z, Zimmermann, AG, Bergstralh, DT, Accavitti-Loper, MA, Morrison, TE, Madden, VJ, Moore, CB	Nature	2008