Reactome | NLRX1 inhibits MAVS-DDX58 interaction

NLRX1 inhibits MAVS-DDX58 interaction

Stable Identifier

R-HSA-936564

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

ReviewStatus

5/5

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NLRX1 is a member of nucleotide-binding domain and leucine-rich repeat containing (NLR) protein family. NLRX1 competes with RIG-I (DDX58) for MAVS (IPS-1) interaction and has been identified as a negative regulator of RLR signaling. NLRX1 resides at the outer mitochondrial membrane where MAVS is located and this interaction is mediated by the CARD region of MAVS (IPS-1) and a putative nucleotide-binding domain (NBD) of NLRX1. This interaction between NLRX1 and MAVS prevents the association of DDX58 (RIG-1) and/or IFIH1 (MDA5) with MAVS.

Literature References

PubMed ID	Title	Journal	Year
18200010	NLRX1 is a regulator of mitochondrial antiviral immunity Moore, CB, Bergstralh, DT, Duncan, JA, Lei, Y, Morrison, TE, Zimmermann, AG, Accavitti-Loper, MA, Madden, VJ, Sun, L, Ye, Z, Lich, JD, Heise, MT, Chen, Z, Ting, JP	Nature	2008