RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS

Stable Identifier
R-HSA-936412
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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RNF125 acts as an E3-ubiquitin ligase that conjugates with RIG-I, MDA5 and IPS-1 and mediate their proteosomal degradation. UbcH1, UbcH5a, UbcH5b, and UbcH5c function as an E2 enzyme and conjugate ubiquitin to RNF125 and RIG-1 via K48. Among these enzymes UbcH5c is the major E2 enzyme showing enhanced ubiquitin conjugation to RIG-I. RNF125 mediated ubiquitination of RIG-I/MDA5 and IPS1 inhibits RIG-I signaling by shunting these proteins toward proteasomal degradation.

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Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of RNF125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol]
Physical Entity
Activity
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Created