Reactome | UBE2L6 [cytosol]

UBE2L6 [cytosol]

Stable Identifier

R-HSA-936014

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UBCH8, Ubiquitin/ISG15-conjugating enzyme E2 L6, UB2L6_HUMAN

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        ISGylation of BECN1 (Homo sapiens)
        
        ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
        
        ISG15:UBCH8 [cytosol] (Homo sapiens)
        
        UBE2L6 [cytosol] (Homo sapiens)
        
        UBE2L6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14933 UBE2L6

Gene Names

UBE2L6, UBCH8

Chain

chain:1-153

Reference Genes

BioGPS Gene:9246 UBE2L6

COSMIC (genes):UBE2L6 UBE2L6

CTD Gene:9246 UBE2L6

dbSNP Gene:9246 UBE2L6

ENSEMBL:ENSG00000156587 UBE2L6

ENSEMBL_homo_sapiens_GENE:ENSG00000156587.16 UBE2L6

HGNC:12490 UBE2L6

KEGG Gene (Homo sapiens):9246 UBE2L6

Monarch:9246 UBE2L6

NCBI Gene:9246 UBE2L6

OMIM:603890 UBE2L6

UCSC:O14933 UBE2L6

Reference Transcript

Other Identifiers

11721994_s_at

16738544

201649_PM_at

201649_at

3373963

3373964

3373965

3373966

3373967

3373972

3373973

3373976

3373977

3373980

3373981

3373982

3373983

40505_at

75081_r_at

7948274

9246

A_23_P75741

GE54567

GO:0000151

GO:0000209

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0016740

GO:0019787

GO:0019941

GO:0030163

GO:0031625

GO:0032020

GO:0032446

GO:0036211

GO:0042296

GO:0043130

GO:0043226

GO:0045087

GO:0061631

GO:0098542

GO:0140096

HMNXSV003001309

ILMN_1703108

ILMN_1769520

ILMN_2252495

PH_hs_0030146

TC11001795.hg

g4759281_3p_at

Participates

as a component of

as an output of

as a candidate of

as a member of

E2 enzymes UbcH8/UBE1L [cytosol] (Homo sapiens)

as an input of

Transfer of ISG15 from E1 to E2 (UBCH8) (Homo sapiens)

Other forms of this molecule

UBE2L6 [nucleoplasm]

Inferred To

Dmel\CG17030 [cytosol] (Drosophila melanogaster)

Homologues of UBE2L6 [cytosol] (Drosophila melanogaster)

Homologues of UBE2L6 [cytosol] (Gallus gallus)

ube2l3a [cytosol] (Danio rerio)

ube2l3 [cytosol] (Xenopus tropicalis)

Ubc10 [cytosol] (Drosophila melanogaster)

Ubc84D [cytosol] (Drosophila melanogaster)

Ghost homologue of UBE2L6 [cytosol] (Canis familiaris)

Ghost homologue of UBE2L6 [cytosol] (Plasmodium falciparum)

UBE2L6 [cytosol] (Bos taurus)

UBE2L6 [cytosol] (Dictyostelium discoideum)

UBE2L6 [cytosol] (Gallus gallus)

UBE2L6 [cytosol] (Sus scrofa)

Ube2l6 [cytosol] (Mus musculus)

Ube2l6 [cytosol] (Rattus norvegicus)

ubc-18 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004214.1, NP_937826.1

OpenTargets

ENSG00000156587

GeneCards

O14933

HPA

ENSG00000156587-UBE2L6

Ensembl

ENST00000287156, ENST00000340573, ENSP00000287156, ENSP00000341980, ENSG00000156587

PRO

O14933

Pharos - Targets

O14933

HMDB Protein

HMDBP00564

PDB

8SE9, 8SEB, 1WZW, 8SEA, 2KJH, 8OIF, 8SV8, 1WZV

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.879	14
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.781	7
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.781	7
UniProt:Q7Z419 RNF144B	1	RNF144B [cytosol] (R-HSA-975988)	0.681	4
UniProt:Q9BZR9 TRIM8	1	TRIM8 [cytosol] (R-HSA-5624332)	0.666	4
UniProt:Q8N9I9 DTX3			0.666	6
UniProt:Q99732 LITAF			0.556	3
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.556	3
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.556	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
IntAct:EBI-23192465 CCSB ORF ID			0.556	5
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.524	3
UniProt:Q8CJB9	1	Rnf40 [nucleoplasm] (R-RNO-5689015)	0.499	2
UniProt:Q99PZ6 OSPG			0.499	2
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.488	2
UniProt:P21605 PG065			0.463	2