Reactome | ATG12 [cytosol]

ATG12 [cytosol]

Stable Identifier

R-HSA-936011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Autophagy-related protein 12, ATG12_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
    - Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
      - Inhibition of DDX58/IFIH1 signaling by ATG5:ATG12:MAVS (Homo sapiens)
        
        ATG5:ATG12:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        ATG5:ATG12 [cytosol] (Homo sapiens)
        
        ATG12 [cytosol] (Homo sapiens)
        
        dsRNA:DDX58, IFIH1:MAVS:ATG5:ATG12 [mitochondrial outer membrane] (Homo sapiens)
        
        ATG5:ATG12:MAVS [mitochondrial outer membrane] (Homo sapiens)
        
        ATG5:ATG12 [cytosol] (Homo sapiens)
        
        ATG12 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O94817 ATG12

Gene Names

ATG12, APG12, APG12L

Chain

chain:1-140

Reference Genes

BioGPS Gene:9140 ATG12

COSMIC (genes):ATG12 ATG12

CTD Gene:9140 ATG12

dbSNP Gene:9140 ATG12

ENSEMBL:ENSG00000145782 ATG12

HGNC:588 ATG12

KEGG:hsa:9140 ATG12

Monarch:9140 ATG12

NCBI Gene:9140 ATG12

OMIM:609608 ATG12

UCSC:O94817 ATG12

Reference Transcript

Other Identifiers

11739320_x_at

11739321_a_at

16999053

204833_3p_at

204833_PM_at

204833_at

213026_PM_at

213026_at

213930_PM_at

213930_at

2871924

2871925

2871926

2871927

2871928

2871929

2871931

2871932

2871933

2871936

2871937

2871938

2871939

2871940

2871941

2871942

2871943

2871944

2871945

2871946

32720_at

32721_at

3769900

3769902

38600_r_at

45493_at

68046_at

8113651

89048_at

9140

A_23_P18901

A_23_P20970

A_24_P680857

A_33_P3418394

GE85885

GE86215

GO:0000045

GO:0000421

GO:0000422

GO:0003824

GO:0005515

GO:0005654

GO:0005737

GO:0005773

GO:0005776

GO:0005829

GO:0005975

GO:0006091

GO:0006914

GO:0007005

GO:0016020

GO:0016236

GO:0016740

GO:0019776

GO:0030670

GO:0032480

GO:0032991

GO:0034045

GO:0034274

GO:0034727

GO:0043226

GO:0043231

GO:0045824

GO:0050687

GO:0061723

GO:0097352

GO:0140096

GO:1901096

GO:1904973

GO:1990234

HMNXSV003024288

Hs.182723.0.S1_3p_at

Hs.264482.1.A1_3p_at

ILMN_1673898

ILMN_2188204

PH_hs_0013658

PH_hs_0034052

TC05003192.hg

g4757757_3p_a_at

g4757757_3p_at

g4757757_3p_s_at

Participates

as a component of

as an input of

ATG12 binds ATG7 dimer (Homo sapiens)

Other forms of this molecule

ATG12 [phagocytic vesicle membrane]

Inferred To

lgg-3 [cytosol] (Caenorhabditis elegans)

ATG12 [cytosol] (Bos taurus)

ATG12 [cytosol] (Canis familiaris)

ATG12 [cytosol] (Gallus gallus)

ATG12 [cytosol] (Plasmodium falciparum)

ATG12 [cytosol] (Saccharomyces cerevisiae)

ATG12 [cytosol] (Sus scrofa)

Atg12 [cytosol] (Drosophila melanogaster)

Atg12 [cytosol] (Mus musculus)

Atg12 [cytosol] (Rattus norvegicus)

atg12 [cytosol] (Danio rerio)

atg12 [cytosol] (Dictyostelium discoideum)

atg12 [cytosol] (Schizosaccharomyces pombe)

atg12 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004698.3, NP_001264712.1

OpenTargets

ENSG00000145782

ENSEMBL

ENSP00000425164, ENST00000509910, ENSP00000425107, ENST00000500945, ENSG00000145782

HPA

ENSG00000145782-ATG12

GeneCards

ATG12

PRO

O94817

Pharos - Targets

O94817

PDB

4GDL, 4GDK, 4NAW

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NT62 ATG3	8	CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) ATG3 [cytosol] (R-HSA-5671860)	0.894	10
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.744	4
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.744	8
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.669	3
UniProt:Q8TDY2 RB1CC1	3	RB1CC1 [endoplasmic reticulum membrane] (R-HSA-8948046) p-RB1CC1 [cytosol] (R-HSA-5675845) RB1CC1 [cytosol] (R-HSA-5333627)	0.564	2
UniProt:O43186 CRX			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q14140 SRTD2			0.556	3
UniProt:Q9BTL4 IER2			0.556	3
UniProt:Q9UHV2 SRTD1			0.556	3
UniProt:Q7Z6L1 TCPR1			0.527	3