Recruitment of IKK complex

Stable Identifier
R-HSA-933539
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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Recruitment of IKK complex
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The molecular mechanisms by which caspase-8/10 attribute to NF-kB signaling is unclear. Caspase-8 might act as a scaffolding protein by bringing the IKK-complex in close proximity to its activator TAK1. The prodomain of Caspase-8 could interact with IKK2 in the IKK complex whereas the protease homology domain failed to do so. These results indicate that the interaction of the DEDs-containing prodomain of caspase-8 with the IKKs may be crucial for the NF-kB induction by caspase-8.
Literature References
PubMed ID Title Journal Year
11002417 Activation of the NF-kappaB pathway by caspase 8 and its homologs

Eby, MT, Liu, L, Hood, L, Kumar, A, Chaudhary, PM, Jasmin, A

Oncogene 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
Recruitment of IKK complex (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Akira, S  (2010-10-30)
Kawai, T  (2010-10-30)
Created
Garapati, P V  (2010-08-16)
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