Recruitment of IKK complex

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
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The molecular mechanisms by which caspase-8/10 attribute to NF-kB signaling is unclear. Caspase-8 might act as a scaffolding protein by bringing the IKK-complex in close proximity to its activator TAK1. The prodomain of Caspase-8 could interact with IKK2 in the IKK complex whereas the protease homology domain failed to do so. These results indicate that the interaction of the DEDs-containing prodomain of caspase-8 with the IKKs may be crucial for the NF-kB induction by caspase-8.

Literature References
PubMed ID Title Journal Year
11002417 Activation of the NF-kappaB pathway by caspase 8 and its homologs

Chaudhary, PM, Eby, MT, Jasmin, A, Kumar, A, Liu, L, Hood, L

Oncogene 2000
Participant Of
Orthologous Events
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