Reactome | Dimerzation of procaspase-8, procaspase-10

Dimerzation of procaspase-8, procaspase-10

Stable Identifier

R-HSA-933523

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

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Dimerzation of procaspase-8, procaspase-10

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Procaspase-8/10 undergo dimerization and the subsequent conformational changes at the receptor complex results in the formation of catalytic active caspase dimers.

Literature References

PubMed ID	Title	Journal	Year
18761323	Non-apoptotic functions of caspase-8 Maelfait, J, Beyaert, R	Biochem Pharmacol	2008
16585540	Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA Takahashi, K, Kawai, T, Kumar, H, Sato, S, Yonehara, S, Akira, S	J Immunol	2006
11717445	Caspase-10 is an initiator caspase in death receptor signaling Wang, J, Chun, HJ, Wong, W, Spencer, DM, Lenardo, MJ	Proc Natl Acad Sci U S A	2001
16618810	Caspases leave the beaten track: caspase-mediated activation of NF-kappaB Lamkanfi, M, Declercq, W, Vanden Berghe, T, Vandenabeele, P	J Cell Biol	2006
12884866	Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases Shikama, Y, Yamada, M, Miyashita, T	Eur J Immunol	2003