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Exon Junction:UPF2:UPF3 Complex [cytosol]
Stable Identifier
R-HSA-927798
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15004547
The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3
Cusack, S
,
Izaurralde, E
,
Kadlec, J
Nat Struct Mol Biol
2004
Participants
components
Core Exon Junction Complex (Core EJC) [cytosol]
(Homo sapiens)
RNPS1 [cytosol]
(Homo sapiens)
UPF2 [cytosol]
(Homo sapiens)
UPF3 [cytosol]
(Homo sapiens)
Participates
as a component of
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
as an input of
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Inferred To
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Bos taurus)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Caenorhabditis elegans)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Canis familiaris)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Danio rerio)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Dictyostelium discoideum)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Drosophila melanogaster)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Gallus gallus)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Mus musculus)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Plasmodium falciparum)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Rattus norvegicus)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Saccharomyces cerevisiae)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Schizosaccharomyces pombe)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Sus scrofa)
Exon Junction:UPF2:UPF3 Complex [cytosol]
(Xenopus tropicalis)
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