Reactome | p-STAT5 dissociates from the receptor complex

p-STAT5 dissociates from the receptor complex

Stable Identifier

R-HSA-921155

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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p-STAT5 dissociates from the receptor complex

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Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).

Literature References

PubMed ID	Title	Journal	Year
9030599	A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation Behrmann, I, Janzen, C, Gerhartz, C, Schmitz-Van de Leur, H, Hermanns, H, Heesel, B, Graeve, L, Horn, F, Tavernier, J, Heinrich, PC	J Biol Chem	1997