Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).
Heinrich, PC, Janzen, C, Horn, F, Schmitz-Van de Leur, H, Behrmann, I, Graeve, L, Heesel, B, Hermanns, H, Tavernier, J, Gerhartz, C
© 2023 Reactome
