Reactome | Phosphorylated STAT5 is released

Phosphorylated STAT5 is released

Stable Identifier

R-HSA-919404

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believe to occur following the release of phosphorylated monomers (e.g. Turkson & Jove 2000).

Literature References

PubMed ID	Title	Journal	Year
9030599	A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation Heinrich, PC, Janzen, C, Horn, F, Schmitz-Van de Leur, H, Behrmann, I, Graeve, L, Heesel, B, Hermanns, H, Tavernier, J, Gerhartz, C	J Biol Chem	1997