TBK1/IKK epsilon complex interacts with MAVS bound TRAF3

Stable Identifier
R-HSA-918225
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
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TRAF3 binds both IPS‑1 and downstream interferon regulatory factor 3/7 (IRF3/7) kinases TBK1 and IKK‑epsilon (IKKi, IKBKE) and thus serves as a critical link between RIG‑I/MDA5 adaptors and downstream regulatory kinases important for interferon regulatory factor (IRF) activation (Oganesyan et al).

SIKE (Suppressor of IKK-epsilon) interacts with IKBKE and TBK1. SIKE is associated with TBK1 under physiological conditions and dissociated from TBK1 upon viral infection. Overexpression of SIKE disrupted the interactions of IKBKE or TBK1 with RIG‑I (DDX58).

SARS-CoV-1 M protein prevents the formation of the TRAF3:TANK:TBK1/IKBKE complex and thereby inhibits TBK1/IKBKE-dependent activation of IRF3/IRF7 transcription factors (Siu KL et al. 2009).

Literature References
PubMed ID Title Journal Year
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Oganesyan, G, Saha, SK, Guo, B, He, JQ, Shahangian, A, Zarnegar, B, Perry, A, Cheng, G

Nature 2006
16281057 SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways

Huang, J, Liu, T, Xu, LG, Chen, D, Zhai, Z, Shu, HB

EMBO J 2005
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