SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+

Stable Identifier
R-HSA-917933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
external side of plasma membrane
Synonyms
Oxidation of Fe2+ by hephaestin
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SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hephaestin oxidizes ferrous iron (Fe2+) to ferric iron (Fe3+) after export from duodenal cells to enable its transport via transferrin (Griffiths et al, 2005).

Literature References
PubMed ID Title Journal Year
16274220 Recombinant expression and functional characterization of human hephaestin: a multicopper oxidase with ferroxidase activity

Griffiths, TA, Mauk, AG, MacGillivray, RT

Biochemistry 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ferroxidase activity of SLC40A1:HEPH:6Cu2+ [plasma membrane]
Physical Entity
SLC40A1:HEPH:6Cu2+ [plasma membrane]
Activity
ferroxidase activity (0004322)
Orthologous Events
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Caenorhabditis elegans)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Canis familiaris)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Danio rerio)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Gallus gallus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Mus musculus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Rattus norvegicus)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Sus scrofa)
SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+ (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-07-04)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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