SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+

Stable Identifier
R-HSA-917891
Type
Reaction
Species
Homo sapiens
Compartment
external side of plasma membrane
Synonyms
Oxidation of Fe2+ by ceruloplasmin
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SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+
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In tissues other than the duodenum, ceruloplasmin (CP), in complex with SLC40A1 and 6 copper ions, oxidises ferrous iron (Fe2+) to ferric iron (Fe3+) after it is exported from the cell (Sato et al. 1990).

Literature References
PubMed ID Title Journal Year
2154449 Detection of multiple forms of human ceruloplasmin. A novel Mr 200,000 form

Sato, M, Morell, AG, Stockert, RJ, Schilsky, ML, Sternlieb, I

J Biol Chem 1990
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as an event of
Catalyst Activity

ferroxidase activity of SLC40A1:CP:6Cu2+ [plasma membrane]

Physical Entity
SLC40A1:CP:6Cu2+ [plasma membrane] (Homo sapiens)
Activity
ferroxidase activity (GO:0004322)
Orthologous Events
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Caenorhabditis elegans)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Canis familiaris)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Danio rerio)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Gallus gallus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Mus musculus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Rattus norvegicus)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Sus scrofa)
SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+ (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2010-07-04)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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