SLC46A1 transports hemes from extracellular region to cytosol

Stable Identifier
R-HSA-917870
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Extracellular ferriheme uptake through the apical membrane of enterocytes
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Uptake of iron from meat happens mostly in the form of ferriheme (FeHM), and via the same transporter that is used for folate. The process is more effective than taking up iron ions (Shayeghi M et al, 2005). In general, heme transporters do not differentiate between ferroheme and ferriheme.

Literature References
PubMed ID Title Journal Year
16143108 Identification of an intestinal heme transporter

Simpson, RJ, McKie, AT, Shayeghi, M, Latunde-Dada, GO, Laftah, AH, Halliday, N, Hider, RC, Anderson, GJ, Frazer, DM, McCann, FE, Khan, Y, Vulpe, CD, Oakhill, JS, Takeuchi, K, Warley, A

Cell 2005
Participants
Participates
Catalyst Activity

heme transmembrane transporter activity of SLC46A1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!