Reactome | SLC46A1 transports hemes from extracellular region to cytosol

SLC46A1 transports hemes from extracellular region to cytosol

Stable Identifier

R-HSA-917870

Type

Reaction

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular ferriheme uptake through the apical membrane of enterocytes

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SLC46A1 transports hemes from extracellular region to cytosol

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Uptake of iron from meat happens mostly in the form of ferriheme (FeHM), and via the same transporter that is used for folate. The process is more effective than taking up iron ions (Shayeghi M et al, 2005). In general, heme transporters do not differentiate between ferroheme and ferriheme.

Literature References

PubMed ID	Title	Journal	Year
16143108	Identification of an intestinal heme transporter Simpson, RJ, McKie, AT, Shayeghi, M, Latunde-Dada, GO, Laftah, AH, Halliday, N, Hider, RC, Anderson, GJ, Frazer, DM, McCann, FE, Khan, Y, Vulpe, CD, Oakhill, JS, Takeuchi, K, Warley, A	Cell	2005