SLC46A1 transports FeHM, heme from extracellular region to cytosol

Stable Identifier
R-HSA-917870
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Extracellular ferriheme uptake through the apical membrane of enterocytes
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SLC46A1 transports FeHM, heme from extracellular region to cytosol
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Uptake of iron from meat happens mostly in the form of ferriheme (FeHM), and via the same transporter that is used for folate. The process is more effective than taking up iron ions (Shayeghi M et al, 2005). In general heme transporters do not differentiate beween ferroheme and ferriheme.

Literature References
PubMed ID Title Journal Year
16143108 Identification of an intestinal heme transporter

Shayeghi, M, Latunde-Dada, GO, Oakhill, JS, Laftah, AH, Takeuchi, K, Halliday, N, Khan, Y, Warley, A, McCann, FE, Hider, RC, Frazer, DM, Anderson, GJ, Vulpe, CD, Simpson, RJ, McKie, AT

Cell 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
heme transporter activity of SLC46A1 [plasma membrane]
Physical Entity
SLC46A1 [plasma membrane]
Activity
heme transporter activity (0015232)
Orthologous Events
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Bos taurus)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Caenorhabditis elegans)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Canis familiaris)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Danio rerio)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Drosophila melanogaster)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Gallus gallus)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Mus musculus)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Rattus norvegicus)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Saccharomyces cerevisiae)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Schizosaccharomyces pombe)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Sus scrofa)
SLC46A1 transports FeHM, heme from extracellular region to cytosol (Xenopus tropicalis)
Authored
Stephan, R  (2010-07-01)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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