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TFRC dimer [plasma membrane]
Stable Identifier
R-HSA-917784
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Transferrin endocytosis and recycling (Homo sapiens)
HFE binds TFRC dimer (Homo sapiens)
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer binds 2xholoTF (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
apo-Transferrin dissociates from the receptor complex (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
apoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
apoTF:TFRC dimer translocates from endosome membrane to plasma membrane (Homo sapiens)
apoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
AP-2 directly binds some endocytic cargo (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
AP-2:cargo [plasma membrane] (Homo sapiens)
AP-2 cargo [plasma membrane] (Homo sapiens)
AP-2 YXXPhi cargo [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
TFRC dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
TFRC(1-760) [plasma membrane]
(Homo sapiens)
Participates
as an output of
apo-Transferrin dissociates from the receptor complex (Homo sapiens)
as a component of
apoTF:TFRC dimer [plasma membrane] (Homo sapiens)
holoTF:TFRC dimer [plasma membrane] (Homo sapiens)
HFE:TFRC dimer [plasma membrane] (Homo sapiens)
as an input of
TFRC dimer binds 2xholoTF (Homo sapiens)
HFE binds TFRC dimer (Homo sapiens)
Inferred To
TFRC dimer [plasma membrane]
(Bos taurus)
TFRC dimer [plasma membrane]
(Caenorhabditis elegans)
TFRC dimer [plasma membrane]
(Canis familiaris)
TFRC dimer [plasma membrane]
(Danio rerio)
TFRC dimer [plasma membrane]
(Gallus gallus)
TFRC dimer [plasma membrane]
(Mus musculus)
TFRC dimer [plasma membrane]
(Rattus norvegicus)
TFRC dimer [plasma membrane]
(Saccharomyces cerevisiae)
TFRC dimer [plasma membrane]
(Schizosaccharomyces pombe)
TFRC dimer [plasma membrane]
(Sus scrofa)
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