GABA loaded synaptic vesicle Docking and Priming

Stable Identifier
R-HSA-917744
Type
Reaction [transition]
Species
Homo sapiens
Compartment
clathrin-sculpted gamma-aminobutyric acid transport vesicle, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GABA loaded synaptic vesicle Docking and Priming
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GABA loaded synaptic vesicles are docked at the presynaptic terminal membrane by a number of proteins including Rab3a, RIM (Rab3a interaction protein) and Munc 13. The docked GABA vesicles are primed by the SNARE complex that includes synaptobrevin, SNAP 25 and syntaxin1.

Literature References
PubMed ID Title Journal Year
16722236 The role of SNARE proteins in trafficking and function of neurotransmitter transporters

Quick, MW

Handb Exp Pharmacol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SNARE binding activity of GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Physical Entity
GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Activity
SNARE binding (0000149)
Orthologous Events
GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)
GABA loaded synaptic vesicle Docking and Priming (Danio rerio)
GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)
GABA loaded synaptic vesicle Docking and Priming (Mus musculus)
GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)
GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)
GABA loaded synaptic vesicle Docking and Priming (Xenopus tropicalis)
Cross References
Target Pathogen
Authored
Mahajan, SS  (2010-08-02)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-07-30)
Cite Us!