GABA loaded synaptic vesicle Docking and Priming

Stable Identifier
R-HSA-917744
Type
Reaction [transition]
Species
Homo sapiens
Compartment
clathrin-sculpted gamma-aminobutyric acid transport vesicle, plasma membrane
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GABA loaded synaptic vesicle Docking and Priming
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GABA loaded synaptic vesicles are docked at the presynaptic terminal membrane by a number of proteins including Rab3a, RIM (Rab3a interaction protein) and Munc 13. The docked GABA vesicles are primed by the SNARE complex that includes synaptobrevin, SNAP 25 and syntaxin1.

Literature References
PubMed ID Title Journal Year
16722236 The role of SNARE proteins in trafficking and function of neurotransmitter transporters

Quick, MW

Handb Exp Pharmacol 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SNARE binding activity of GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Physical Entity
GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Activity
SNARE binding (0000149)
Orthologous Events
GABA loaded synaptic vesicle Docking and Priming (Caenorhabditis elegans)
GABA loaded synaptic vesicle Docking and Priming (Danio rerio)
GABA loaded synaptic vesicle Docking and Priming (Drosophila melanogaster)
GABA loaded synaptic vesicle Docking and Priming (Gallus gallus)
GABA loaded synaptic vesicle Docking and Priming (Mus musculus)
GABA loaded synaptic vesicle Docking and Priming (Rattus norvegicus)
GABA loaded synaptic vesicle Docking and Priming (Sus scrofa)
GABA loaded synaptic vesicle Docking and Priming (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-08-02)
Reviewed
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-07-30)