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CHMP4A [cytosol]
Stable Identifier
R-HSA-917733
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Charged multivesicular body protein 4a, CHM4A_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9BSW7 SYT17
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BY43 CHMP4A
Gene Names
CHMP4A, C14orf123, SHAX2, CDA04, HSPC134
Chain
chain:1-222
Reference Genes
BioGPS Gene:29082 CHMP4A
COSMIC (genes):CHMP4A CHMP4A
CTD Gene:29082 CHMP4A
dbSNP Gene:29082 CHMP4A
ENSEMBL:ENSG00000254505 CHMP4A
HGNC:20274 CHMP4A
KEGG:hsa:29082 CHMP4A
Monarch:29082 CHMP4A
NCBI Gene:29082 CHMP4A
OMIM:610051 CHMP4A
UCSC:Q9BY43 CHMP4A
Reference Transcript
RefSeq:NM_014169.3 CHMP4A
Participates
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as a member of
CHMP4 [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP4A [endosome membrane]
Inferred To
snf7 [cytosol]
(Schizosaccharomyces pombe)
CHMP4A [cytosol]
(Bos taurus)
CHMP4A [cytosol]
(Canis familiaris)
CHMP4A [cytosol]
(Sus scrofa)
SNF7 [cytosol]
(Saccharomyces cerevisiae)
chmp4 [cytosol]
(Dictyostelium discoideum)
vps-32.1 [cytosol]
(Caenorhabditis elegans)
shrb [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_054888.2
ENSEMBL
ENSP00000324205
,
ENST00000645308
,
ENST00000347519
,
ENSP00000495982
,
ENSG00000285302
,
ENSG00000254505
OpenTargets
ENSG00000254505
GeneCards
CHMP4A
HPA
ENSG00000254505-CHMP4A
PRO
Q9BY43
Pharos - Targets
Q9BY43
PDB
5MK1
,
3C3O
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BSW7 SYT17
0.8
6
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.683
3
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.553
2
UniProt:Q99618 CDCA3
0.527
2
UniProt:Q9UIW0 VAX2
0.527
2
UniProt:Q8N6S5 AR6P6
0.527
2
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