Reactome | CHMP4A [cytosol]

CHMP4A [cytosol]

Stable Identifier

R-HSA-917733

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Charged multivesicular body protein 4a, CHM4A_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BY43 CHMP4A

Gene Names

CHMP4A, C14orf123, SHAX2, CDA04, HSPC134

Chain

chain:1-222

Reference Genes

BioGPS Gene:29082 CHMP4A

COSMIC (genes):CHMP4A CHMP4A

CTD Gene:29082 CHMP4A

dbSNP Gene:29082 CHMP4A

ENSEMBL:ENSG00000254505 CHMP4A

ENSEMBL:ENSG00000254505.11 CHMP4A

ENSEMBL:ENSG00000285302.5 CHMP4A

HGNC:20274 CHMP4A

KEGG Gene (Homo sapiens):29082 CHMP4A

Monarch:29082 CHMP4A

NCBI Gene:29082 CHMP4A

OMIM:610051 CHMP4A

UCSC:Q9BY43 CHMP4A

Reference Transcript

RefSeq:NM_014169.3 CHMP4A

Other Identifiers

11722579_a_at

11722580_at

16791153

218571_PM_s_at

218571_s_at

218572_PM_at

218572_at

228764_PM_s_at

228764_s_at

29082

3557946

3557948

3557949

3557950

3557952

3557954

3557956

3557957

3557959

3557961

3557962

3557963

3557969

3557970

3557971

3557972

58474_at

64089_at

7978174

7978187

A_23_P106226

A_23_P99811

A_24_P142024

GE62173

GO:0000278

GO:0000421

GO:0000776

GO:0000815

GO:0000910

GO:0001778

GO:0005515

GO:0005634

GO:0005635

GO:0005643

GO:0005694

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005771

GO:0005773

GO:0005828

GO:0005829

GO:0005856

GO:0005886

GO:0006620

GO:0006886

GO:0006900

GO:0006914

GO:0006997

GO:0007010

GO:0007034

GO:0007040

GO:0007059

GO:0007080

GO:0008289

GO:0008333

GO:0009898

GO:0010324

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0030117

GO:0030163

GO:0030496

GO:0030659

GO:0031410

GO:0031468

GO:0031902

GO:0032511

GO:0032585

GO:0036258

GO:0039702

GO:0042060

GO:0042802

GO:0042803

GO:0043162

GO:0043226

GO:0046761

GO:0051117

GO:0051258

GO:0051469

GO:0060548

GO:0061024

GO:0061763

GO:0061952

GO:0065003

GO:0071985

GO:0090148

GO:0097320

GO:0097352

GO:0140014

GO:1901215

GO:1901673

GO:1902774

GO:1902902

GO:1904930

HMNXSV003039930

ILMN_1715607

PH_hs_0014395

TC14002341.hg

g7661793_3p_s_at

Participates

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as an input of

CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)

as a member of

CHMP4 [cytosol] (Homo sapiens)

Other forms of this molecule

CHMP4A [endosome membrane]

Inferred To

snf7 [cytosol] (Schizosaccharomyces pombe)

CHMP4A [cytosol] (Bos taurus)

CHMP4A [cytosol] (Canis familiaris)

CHMP4A [cytosol] (Sus scrofa)

SNF7 [cytosol] (Saccharomyces cerevisiae)

chmp4 [cytosol] (Dictyostelium discoideum)

vps-32.1 [cytosol] (Caenorhabditis elegans)

shrb [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_054888.2

OpenTargets

ENSG00000254505

GeneCards

Q9BY43

HPA

ENSG00000254505-CHMP4A

Ensembl

ENSP00000324205, ENSG00000254505, ENSP00000495982, ENST00000347519, ENST00000645308, ENSG00000285302

PRO

Q9BY43

Pharos - Targets

Q9BY43

PDB

3C3O, 5MK1

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BSW7 SYT17			0.8	6
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.683	3
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.553	2

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