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CHMP4A [cytosol]
Stable Identifier
R-HSA-917733
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Charged multivesicular body protein 4a, CHM4A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Autophagosome maturation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
CHMP7 binds CC2D1B (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B [nuclear envelope] (Homo sapiens)
LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
HCMV Final Envelopment (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
HCMV Formation of Final Envelopment Complex (Homo sapiens)
ESCRT Regulator Complex [cytosol] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Enhanced autophagosome formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
Pyroptosis (Homo sapiens)
GSDMD forms ring‐shaped oligomers (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
ESCRT Disassembly (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
MVB Vesicle Formation (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
ESCRT-III/Cargo Complex [endosome membrane] (Homo sapiens)
ESCRT-III [cytosol] (Homo sapiens)
CHMP4 [cytosol] (Homo sapiens)
CHMP4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BY43 CHMP4A
Gene Names
CHMP4A, C14orf123, SHAX2, CDA04, HSPC134
Chain
chain:1-222
Reference Genes
BioGPS Gene:29082 CHMP4A
COSMIC (genes):CHMP4A CHMP4A
CTD Gene:29082 CHMP4A
dbSNP Gene:29082 CHMP4A
ENSEMBL:ENSG00000254505 CHMP4A
ENSEMBL:ENSG00000254505.11 CHMP4A
ENSEMBL:ENSG00000285302.5 CHMP4A
HGNC:20274 CHMP4A
KEGG Gene (Homo sapiens):29082 CHMP4A
Monarch:29082 CHMP4A
NCBI Gene:29082 CHMP4A
OMIM:610051 CHMP4A
UCSC:Q9BY43 CHMP4A
Reference Transcript
RefSeq:NM_014169.3 CHMP4A
Other Identifiers
11722579_a_at
11722580_at
16791153
218571_PM_s_at
218571_s_at
218572_PM_at
218572_at
228764_PM_s_at
228764_s_at
29082
3557946
3557948
3557949
3557950
3557952
3557954
3557956
3557957
3557959
3557961
3557962
3557963
3557969
3557970
3557971
3557972
58474_at
64089_at
7978174
7978187
A_23_P106226
A_23_P99811
A_24_P142024
GE62173
GO:0000278
GO:0000421
GO:0000776
GO:0000815
GO:0000910
GO:0001778
GO:0005515
GO:0005634
GO:0005635
GO:0005643
GO:0005694
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005771
GO:0005773
GO:0005828
GO:0005829
GO:0005856
GO:0005886
GO:0006620
GO:0006886
GO:0006900
GO:0006914
GO:0006997
GO:0007010
GO:0007034
GO:0007040
GO:0007059
GO:0007080
GO:0008289
GO:0008333
GO:0009898
GO:0010324
GO:0015031
GO:0016020
GO:0016192
GO:0016236
GO:0030117
GO:0030163
GO:0030496
GO:0030659
GO:0031410
GO:0031468
GO:0031902
GO:0032511
GO:0032585
GO:0036258
GO:0039702
GO:0042060
GO:0042802
GO:0042803
GO:0043162
GO:0043226
GO:0046761
GO:0051117
GO:0051258
GO:0051469
GO:0060548
GO:0061024
GO:0061763
GO:0061952
GO:0065003
GO:0071985
GO:0090148
GO:0097320
GO:0097352
GO:0140014
GO:1901215
GO:1901673
GO:1902774
GO:1902902
GO:1904930
HMNXSV003039930
ILMN_1715607
PH_hs_0014395
TC14002341.hg
g7661793_3p_s_at
Participates
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)
as a member of
CHMP4 [cytosol] (Homo sapiens)
Other forms of this molecule
CHMP4A [endosome membrane]
Inferred To
snf7 [cytosol]
(Schizosaccharomyces pombe)
CHMP4A [cytosol]
(Bos taurus)
CHMP4A [cytosol]
(Canis familiaris)
CHMP4A [cytosol]
(Sus scrofa)
SNF7 [cytosol]
(Saccharomyces cerevisiae)
chmp4 [cytosol]
(Dictyostelium discoideum)
vps-32.1 [cytosol]
(Caenorhabditis elegans)
shrb [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_054888.2
OpenTargets
ENSG00000254505
GeneCards
Q9BY43
HPA
ENSG00000254505-CHMP4A
Ensembl
ENSP00000324205
,
ENSG00000254505
,
ENSP00000495982
,
ENST00000347519
,
ENST00000645308
,
ENSG00000285302
PRO
Q9BY43
Pharos - Targets
Q9BY43
PDB
3C3O
,
5MK1
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BSW7 SYT17
0.8
6
UniProt:Q8WUM4 PDCD6IP
1
PDCD6IP [cytosol]
(R-HSA-917717)
0.683
3
UniProt:O95630 STAMBP
1
STAMBP [cytosol]
(R-HSA-5693063)
0.553
2
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