Cargo Recognition And Sorting

Stable Identifier
R-HSA-917730
Type
Reaction
Species
Homo sapiens
Compartment
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Initiation/Cargo Recognition is mediated by ESCRT-0, a heterodimer consisting of Vps27 and Hse1. ESCRT-0 binds Phosphatidyl inositol 3- phosphate (PI3P) on endosomes via a FVYE domain and ubiquitinated cargo via two UIM domains.

Literature References
PubMed ID Title Journal Year
14624836 Hrs function: viruses provide the clue

Clague, MJ, Urbé, S

Trends Cell Biol 2003
15218037 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding

Stuchell, MD, Garrus, JE, Muller, B, Stray, KM, Ghaffarian, S, McKinnon, R, Krausslich, HG, Morham, SG, Sundquist, WI

J Biol Chem 2004
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Orthologous Events
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