Cargo Recognition And Sorting

Stable Identifier
R-HSA-917730
Type
Reaction
Species
Homo sapiens
Compartment
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Initiation/Cargo Recognition is mediated by ESCRT-0, a heterodimer consisting of Vps27 and Hse1. ESCRT-0 binds Phosphatidyl inositol 3- phosphate (PI3P) on endosomes via a FVYE domain and ubiquitinated cargo via two UIM domains.

Literature References
PubMed ID Title Journal Year
15218037 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding

Ghaffarian, S, Stuchell, MD, Garrus, JE, Sundquist, WI, McKinnon, R, Muller, B, Stray, KM, Krausslich, HG, Morham, SG

J Biol Chem 2004
14624836 Hrs function: viruses provide the clue

Urbé, S, Clague, MJ

Trends Cell Biol 2003
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