Initiation/Cargo Recognition is mediated by ESCRT-0, a heterodimer consisting of Vps27 and Hse1. ESCRT-0 binds Phosphatidyl inositol 3- phosphate (PI3P) on endosomes via a FVYE domain and ubiquitinated cargo via two UIM domains.
Clague, MJ, Urbé, S
Stuchell, MD, Garrus, JE, Muller, B, Stray, KM, Ghaffarian, S, McKinnon, R, Krausslich, HG, Morham, SG, Sundquist, WI
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