Cargo Recognition And Sorting

Stable Identifier
R-HSA-917730
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
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Cargo Recognition And Sorting
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Initiation/Cargo Recognition is mediated by ESCRT-0, a heterodimer consisting of Vps27 and Hse1. ESCRT-0 binds Phosphatidyl inositol 3- phosphate (PI3P) on endosomes via a FVYE domain and ubiquitinated cargo via two UIM domains.

Literature References
PubMed ID Title Journal Year
14624836 Hrs function: viruses provide the clue

Clague, MJ, Urbé, S

Trends Cell Biol 2003
15218037 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding

Stuchell, MD, Garrus, JE, Muller, B, Stray, KM, Ghaffarian, S, McKinnon, R, Krausslich, HG, Morham, SG, Sundquist, WI

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Cargo Recognition And Sorting (Bos taurus)
Cargo Recognition And Sorting (Caenorhabditis elegans)
Cargo Recognition And Sorting (Canis familiaris)
Cargo Recognition And Sorting (Danio rerio)
Cargo Recognition And Sorting (Drosophila melanogaster)
Cargo Recognition And Sorting (Gallus gallus)
Cargo Recognition And Sorting (Mus musculus)
Cargo Recognition And Sorting (Rattus norvegicus)
Cargo Recognition And Sorting (Sus scrofa)
Cargo Recognition And Sorting (Xenopus tropicalis)
Cross References
Target Pathogen
Authored
Gillespie, ME  (2010-08-10)
Reviewed
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2010-07-30)