Reactome | MVB Vesicle Formation

MVB Vesicle Formation

Stable Identifier

R-HSA-917700

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ESCRT-III assembles into a highly ordered filament-like hetero-oligomer. Vps20 nucleates the homo-oligomerization of Snf7 that is capped by Vps24. Vps24 recruits Vps2 and initiates Vps4-dependent ESCRT-III disassembly. ESCRT-III is required for the last steps of MVB sorting, cargo sequestration, and MVB vesicle formation.

Literature References

PubMed ID	Title	Journal	Year
16371348	Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII Bowers, K, Owen, DJ, Gray, SR, Luzio, JP, Piper, SC, Lehner, PJ, Edeling, MA	J Biol Chem	2006
16973552	Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release Langelier, C, Kaplan, J, Sundquist, WI, von Schwedler, UK, Ward, D, De Domenico, I, Fisher, RD, White, PL, Hill, CP	J Virol	2006