MVB Vesicle Formation

Stable Identifier
R-HSA-917700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ESCRT-III assembles into a highly ordered filament-like hetero-oligomer. Vps20 nucleates the homo-oligomerization of Snf7 that is capped by Vps24. Vps24 recruits Vps2 and initiates Vps4-dependent ESCRT-III disassembly. ESCRT-III is required for the last steps of MVB sorting, cargo sequestration, and MVB vesicle formation.

Literature References
PubMed ID Title Journal Year
16973552 Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release

Langelier, C, von Schwedler, UK, Fisher, RD, De Domenico, I, White, PL, Hill, CP, Kaplan, J, Ward, D, Sundquist, WI

J Virol 2006
16371348 Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

Bowers, K, Piper, SC, Edeling, MA, Gray, SR, Owen, DJ, Lehner, PJ, Luzio, JP

J Biol Chem 2006
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