Cargo Sequestration

Stable Identifier
R-HSA-917696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
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Cargo Sequestration
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ESCRT-0 recruits ESCRT-I and thereby initiates the MVB pathway. Cargo Sorting ESCRT-I is a heterotetramer consisting of Vps23, Vps28, Vps37 (VPS37A, VPS37B, VPS37C or VPS37D), and Mvb12/Ubap1 (MVB12A, MVB12B or UBAP1). The UEV domain of Vps23 binds ubiquitinated membrane proteins. Vps28 interacts with the GLUE domain of Vps36 in ESCRT-II. Cargo Sorting ESCRT-II is a heterotetramer formed of Vps36, Vps22, and two Vps25 molecules. The GLUE domain of Vps36 binds PI3P, Vps28, and ubiquitinated membrane proteins. Vps25 interacts with Vps20 of ESCRT-III.

Literature References
PubMed ID Title Journal Year
21757351 UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting

Stefani, F, Zhang, L, Taylor, S, Donovan, J, Rollinson, S, Doyotte, A, Brownhill, K, Bennion, J, Pickering-Brown, S, Woodman, P

Curr. Biol. 2011
15218037 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding

Stuchell, MD, Garrus, JE, Muller, B, Stray, KM, Ghaffarian, S, McKinnon, R, Krausslich, HG, Morham, SG, Sundquist, WI

J Biol Chem 2004
Participants
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Output
Participant Of
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Orthologous Events
Cargo Sequestration (Bos taurus)
Cargo Sequestration (Caenorhabditis elegans)
Cargo Sequestration (Danio rerio)
Cargo Sequestration (Dictyostelium discoideum)
Cargo Sequestration (Drosophila melanogaster)
Cargo Sequestration (Gallus gallus)
Cargo Sequestration (Mus musculus)
Cargo Sequestration (Rattus norvegicus)
Cargo Sequestration (Sus scrofa)
Cargo Sequestration (Xenopus tropicalis)
Authored
Gillespie, ME  (2010-08-10)
Reviewed
Rush, MG  (2008-01-11)
Created
Gillespie, ME  (2010-07-30)