Reactome | Cargo Sequestration

Cargo Sequestration

Stable Identifier

R-HSA-917696

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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ESCRT-0 recruits ESCRT-I and thereby initiates the MVB pathway. Cargo Sorting ESCRT-I is a heterotetramer consisting of Vps23, Vps28, Vps37 (VPS37A, VPS37B, VPS37C or VPS37D), and Mvb12/Ubap1 (MVB12A, MVB12B or UBAP1). The UEV domain of Vps23 binds ubiquitinated membrane proteins. Vps28 interacts with the GLUE domain of Vps36 in ESCRT-II. Cargo Sorting ESCRT-II is a heterotetramer formed of Vps36, Vps22, and two Vps25 molecules. The GLUE domain of Vps36 binds PI3P, Vps28, and ubiquitinated membrane proteins. Vps25 interacts with Vps20 of ESCRT-III.

Literature References

PubMed ID	Title	Journal	Year
15218037	The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding Stuchell, MD, Garrus, JE, Muller, B, Stray, KM, Ghaffarian, S, McKinnon, R, Krausslich, HG, Morham, SG, Sundquist, WI	J Biol Chem	2004
21757351	UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting Stefani, F, Zhang, L, Taylor, S, Donovan, J, Rollinson, S, Doyotte, A, Brownhill, K, Bennion, J, Pickering-Brown, S, Woodman, P	Curr. Biol.	2011