Degradation of GABA

Stable Identifier
R-HSA-916853
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
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Degradation of GABA
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GABA is metabolized in the mitochondrial matrix to succinate by the serial action of two enzymes, 4-aminobutyrate aminotransferase and suucinate semialdehyde dehydrogenase. Failure of the second reaction is associated with a rare human genetic disorder (Malaspina et al. 2016; Pearl et al. 2009).

Literature References
PubMed ID Title Journal Year
19172412 Succinic semialdehyde dehydrogenase deficiency: lessons from mice and men

Pettiford, JM, Forester, K, Wu, Y, Theodore, WH, Knerr, I, Carter Snead O, 3rd, Cortez, MA, Gibson, KM, Pearl, P L, Jakobs, C

J Inherit Metab Dis 2009
27311541 Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

Roullet, JB, Gibson, KM, Ainslie, GR, Pearl, P L, Malaspina, P, Vogel, KR

Neurochem. Int. 2016
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Events
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as an event of
Event Information
Go Biological Process
gamma-aminobutyric acid catabolic process (0009450)
Orthologous Events
Degradation of GABA (Bos taurus)
Degradation of GABA (Caenorhabditis elegans)
Degradation of GABA (Canis familiaris)
Degradation of GABA (Danio rerio)
Degradation of GABA (Dictyostelium discoideum)
Degradation of GABA (Drosophila melanogaster)
Degradation of GABA (Gallus gallus)
Degradation of GABA (Mus musculus)
Degradation of GABA (Rattus norvegicus)
Degradation of GABA (Saccharomyces cerevisiae)
Degradation of GABA (Schizosaccharomyces pombe)
Degradation of GABA (Sus scrofa)
Degradation of GABA (Xenopus tropicalis)
Authored
Mahajan, SS  (2010-07-31)
Reviewed
Jassal, B  (2019-07-15)
Restituito, S  (2008-11-27)
Created
Mahajan, SS  (2010-07-29)
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