Reactome | ALDH5A1 [mitochondrial matrix]

ALDH5A1 [mitochondrial matrix]

Stable Identifier

R-HSA-916831

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Succinate-semialdehyde dehydrogenase, mitochondrial, SSDH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P51649 ALDH5A1

Gene Names

ALDH5A1, SSADH

Chain

transit peptide:1-47, chain:48-535

Reference Genes

BioGPS Gene:7915 ALDH5A1

COSMIC (genes):ALDH5A1 ALDH5A1

CTD Gene:7915 ALDH5A1

dbSNP Gene:7915 ALDH5A1

ENSEMBL:ENSG00000112294 ALDH5A1

ENSEMBL_homo_sapiens_GENE:ENSG00000112294.14 ALDH5A1

HGNC:408 ALDH5A1

KEGG Gene (Homo sapiens):7915 ALDH5A1

Monarch:7915 ALDH5A1

NCBI Gene:7915 ALDH5A1

OMIM:610045 ALDH5A1

Reference Transcript

Other Identifiers

11719359_a_at

11736619_a_at

17005368

203608_PM_at

203608_at

203609_PM_s_at

203609_s_at

2898505

2898506

2898507

2898508

2898509

2898510

2898511

2898512

2898514

2898515

2898517

2898519

2898522

2898523

2898524

2898525

2898526

2898527

2898528

2898529

2898530

2898531

41790_at

7915

8117207

A_24_P115007

A_24_P3761

A_24_P923353

GE56079

GE80979

GO:0003824

GO:0004777

GO:0005739

GO:0005759

GO:0006105

GO:0006520

GO:0006536

GO:0007417

GO:0009013

GO:0009448

GO:0009450

GO:0009791

GO:0016491

GO:0016620

GO:0023052

GO:0042802

GO:0043226

GO:0045202

GO:0048856

GO:0051932

HMNXSV003000063

Hs.5299.0.S2_3p_at

ILMN_2372398

ILMN_2372403

L34820_at

PH_hs_0000540

TC06000146.hg

TC06002625.hg

g4507228_3p_a_at

Participates

as a component of

ALDH5A1 tetramer [mitochondrial matrix] (Homo sapiens)

Inferred To

Ssadh [mitochondrial matrix] (Drosophila melanogaster)

UGA2 [mitochondrial matrix] (Saccharomyces cerevisiae)

alh-7 [mitochondrial matrix] (Caenorhabditis elegans)

aldh5a1 [mitochondrial matrix] (Xenopus tropicalis)

ALDH5A1 [mitochondrial matrix] (Bos taurus)

ALDH5A1 [mitochondrial matrix] (Canis familiaris)

ALDH5A1 [mitochondrial matrix] (Gallus gallus)

ALDH5A1 [mitochondrial matrix] (Mus musculus)

ALDH5A1 [mitochondrial matrix] (Rattus norvegicus)

ALDH5A1 [mitochondrial matrix] (Schizosaccharomyces pombe)

ALDH5A1 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_001071.1, NP_733936.1

Guide to Pharmacology - Targets

2466

OpenTargets

ENSG00000112294

ZINC - Substances

SSDH_HUMAN

ZINC target

P51649

PRO

P51649

PDB

2W8P, 2W8O, 2W8R, 2W8Q, 2W8N

IntEnz

1.2.1.24

GeneCards

P51649

HPA

ENSG00000112294-ALDH5A1

Ensembl

ENST00000357578, ENSP00000350191, ENST00000348925, ENSG00000112294, ENSP00000314649

Pharos - Targets

P51649

ZINC - Predictions - Purchasable

SSDH_HUMAN

Orphanet

15489

HMDB Protein

HMDBP00249

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