Reactome | IL3RB is phosphorylated on Ser-585

IL3RB is phosphorylated on Ser-585

Stable Identifier

R-HSA-913451

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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GM-CSF and IL-3 application lead to Ser-585 phosphorylation of the Common beta chain (Bc) shared with the IL-3 and IL-5 receptors (Stomski et al. 1999, Guthridge et al. 2000). PKA was identified as capable of phosphorylating Bc at S585 (Guthridge et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10477722	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF Stomski, FC, Dottore, M, Winnall, W, Guthridge, MA, Woodcock, J, Bagley, CJ, Thomas, DT, Andrews, RK, Berndt, MC, Lopez, AF	Blood	1999
10949031	Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival Guthridge, MA, Stomski, FC, Barry, EF, Winnall, W, Woodcock, JM, McClure, BJ, Dottore, M, Berndt, MC, Lopez, AF	Mol Cell	2000