Reactome | p-S585-IL3RB binds 14-3-3 proteins

p-S585-IL3RB binds 14-3-3 proteins

Stable Identifier

R-HSA-912757

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The common beta chain (Bc), binds 14-3-3 zeta at a site that requires phosphorylation of Serine 585 (Stomski et al. 1999). Bc modifications that prevent Ser-585 phosphorylation do not recruit 14-3-3 zeta (Guthridge et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10477722	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF Stomski, FC, Dottore, M, Winnall, W, Guthridge, MA, Woodcock, J, Bagley, CJ, Thomas, DT, Andrews, RK, Berndt, MC, Lopez, AF	Blood	1999