Reactome | CBL:CRKL binds RAPGEF1

CBL:CRKL binds RAPGEF1

Stable Identifier

R-HSA-912734

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cbl has been identified in ternary complexes with CRKL and C3G (RAPGEF1)(Reedquist et al. 1996) a Rap1 GEF, suggesting a role for Cbl in linking cytokine stimulation to Rap1 activation. Consistent with this, stimulation of NB-4 promyelocytic cells by IFN-gamma causes tyrosine phosphorylation and association of Cbl with CRKL followed by activation of Rap1 (Alsayed et al. 2000) and tyrosine phosphorylation of Cbl and its association with CRKL correlated with an increase in Rap 1 activity in anergic T cells (Boussiotis et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8626543	Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G Shoelson, SE, Langdon, WY, Reedquist, KA, Panchamoorthy, G, Band, H, Druker, BJ, Fukazawa, T	J Biol Chem	1996