CBL:CRKL binds RAPGEF1

Stable Identifier
R-HSA-912734
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cbl has been identified in ternary complexes with CRKL and C3G (RAPGEF1)(Reedquist et al. 1996) a Rap1 GEF, suggesting a role for Cbl in linking cytokine stimulation to Rap1 activation. Consistent with this, stimulation of NB-4 promyelocytic cells by IFN-gamma causes tyrosine phosphorylation and association of Cbl with CRKL followed by activation of Rap1 (Alsayed et al. 2000) and tyrosine phosphorylation of Cbl and its association with CRKL correlated with an increase in Rap 1 activity in anergic T cells (Boussiotis et al. 1997).

Literature References
PubMed ID Title Journal Year
8626543 Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

Reedquist, KA, Fukazawa, T, Panchamoorthy, G, Langdon, WY, Shoelson, SE, Druker, BJ, Band, H

J Biol Chem 1996
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