Reactome | CBL binds VAV

CBL binds VAV

Stable Identifier

R-HSA-912727

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.

Literature References

PubMed ID	Title	Journal	Year
9200440	Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells Penninger, JM, Kozieradzki, I, Marengère, LE, Veillette, A, Mak, TW, Mirtsos, C	J Immunol	1997
12881521	Cbl-mediated ubiquitinylation and negative regulation of Vav Miura-Shimura, Y, Rottapel, R, Rao, NL, Duan, L, Reddi, AL, Band, H, Druker, BJ, Shimura, H, Tsygankov, A, Band, V	J Biol Chem	2003