Reactome | CBL binds VAV

CBL binds VAV

Stable Identifier

R-HSA-912727

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.

Literature References

PubMed ID	Title	Journal	Year
9200440	Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells Marengère, LE, Mirtsos, C, Kozieradzki, I, Veillette, A, Mak, TW, Penninger, JM	J Immunol	1997
12881521	Cbl-mediated ubiquitinylation and negative regulation of Vav Miura-Shimura, Y, Duan, L, Rao, NL, Reddi, AL, Shimura, H, Rottapel, R, Druker, BJ, Tsygankov, A, Band, V, Band, H	J Biol Chem	2003