Reactome | DMC1 [nucleoplasm]

DMC1 [nucleoplasm]

Stable Identifier

R-HSA-912490

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Meiotic recombination protein DMC1/LIM15 homolog, DMC1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9H190 SDCB2

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External Reference Information

External Reference

UniProt:Q14565 DMC1

Gene Names

DMC1, DMC1H, LIM15

Chain

chain:1-340

Reference Genes

BioGPS Gene:11144 DMC1

COSMIC (genes):DMC1 DMC1

CTD Gene:11144 DMC1

dbSNP Gene:11144 DMC1

ENSEMBL:ENSG00000100206 DMC1

HGNC:2927 DMC1

KEGG:hsa:11144 DMC1

Monarch:11144 DMC1

NCBI Gene:11144 DMC1

OMIM:602721 DMC1

UCSC:Q14565 DMC1

Reference Transcript

Other Identifiers

11144

11738000_a_at

16935069

208382_PM_s_at

208382_s_at

208386_PM_x_at

208386_x_at

34579_r_at

3960686

3960687

3960688

3960691

3960692

3960693

3960694

3960697

3960698

3960699

3960700

3960701

3960705

3960706

3960707

3960708

3960709

3960712

8076094

A_23_P361381

A_24_P288612

D63882_s_at

D64108_at

GE57288

GO:0000150

GO:0000166

GO:0000228

GO:0000724

GO:0000730

GO:0000781

GO:0000794

GO:0000800

GO:0001541

GO:0001556

GO:0003677

GO:0003690

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006281

GO:0006310

GO:0006312

GO:0007129

GO:0007131

GO:0007141

GO:0007276

GO:0007283

GO:0007286

GO:0007292

GO:0008094

GO:0016787

GO:0016887

GO:0022414

GO:0035861

GO:0042148

GO:0042802

GO:0043226

GO:0048477

GO:0048856

GO:0051321

GO:0065003

GO:0070192

GO:0140013

GO:0140097

GO:0140299

GO:0140657

GO:0140664

GO:1990918

HMNXSV003010663

HMNXSV003043430

HMNXSV003049686

ILMN_1812545

ILMN_2162367

PH_hs_0023883

TC22000792.hg

TC22001346.hg

g1066000_3p_a_at

Participates

as a member of

DMC1, RAD51 [nucleoplasm] (Homo sapiens)

as an input of

Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)

as a component of

as an output of

Formation of meiotic holliday junction (Homo sapiens)

Inferred To

DMC1 [nucleoplasm] (Bos taurus)

DMC1 [nucleoplasm] (Canis familiaris)

DMC1 [nucleoplasm] (Gallus gallus)

DMC1 [nucleoplasm] (Sus scrofa)

dmc1 [nucleoplasm] (Danio rerio)

Dmc1 [nucleoplasm] (Mus musculus)

Dmc1 [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000100206

ENSEMBL

ENST00000216024, ENST00000428462, ENSP00000216024, ENSP00000412703

HPA

ENSG00000100206-DMC1

PRO

Q14565

Pharos - Targets

Q14565

PDB

8R2G, 8QQE, 7C99, 7CGY, 4HYY, 7C9C, 7C98, 6R3P, 1V5W, 2ZJB

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZT8 NIF3L			0.805	9
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.781	7
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.781	7
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.781	8
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.765	12
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.668	3
UniProt:Q8N5Z5 KCD17			0.666	4
UniProt:Q96B01-2 RAD51AP1			0.623	3
UniProt:O75928-2 PIAS2	1	PIAS2-2 [nucleoplasm] (R-HSA-2993779)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9H190 SDCB2			0.556	3
IntAct:EBI-12701076 KCTD17			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P36406 TRI23			0.556	3
IntAct:EBI-10233454 79734			0.556	3
UniProt:A5A3E0 POTEF			0.527	2
UniProt:P68133 ACTA1	1	ACTA1 [cytosol] (R-HSA-390534)	0.527	2
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.527	2

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