Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MSH4 [nucleoplasm]
Stable Identifier
R-HSA-912455
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MutS protein homolog 4, MSH4_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
MSH4:MSH5 [nucleoplasm] (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
MSH4:MSH5 [nucleoplasm] (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
MSH4:MSH5 [nucleoplasm] (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
MSH4:MSH5 [nucleoplasm] (Homo sapiens)
MSH4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15457 MSH4
Gene Names
MSH4
Chain
chain:1-936
Reference Genes
BioGPS Gene:4438 MSH4
COSMIC (genes):MSH4 MSH4
CTD Gene:4438 MSH4
dbSNP Gene:4438 MSH4
ENSEMBL:ENSG00000057468 MSH4
HGNC:7327 MSH4
KEGG:hsa:4438 MSH4
Monarch:4438 MSH4
NCBI Gene:4438 MSH4
OMIM:602105 MSH4
UCSC:O15457 MSH4
Reference Transcript
RefSeq:NM_002440.3 MSH4
Other Identifiers
11744316_at
16666296
210533_PM_at
210533_at
2342666
2342667
2342668
2342671
2342672
2342673
2342674
2342675
2342676
2342677
2342678
2342680
2342683
2342684
2342685
2342686
2342687
2342688
2342689
2342690
2342691
2342692
2342694
2342695
2342696
2342697
2342698
31714_at
4438
7902402
A_23_P74068
GE80320
GO:0000228
GO:0000793
GO:0000794
GO:0000795
GO:0001541
GO:0003677
GO:0003690
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005713
GO:0006281
GO:0006298
GO:0006310
GO:0007129
GO:0007131
GO:0007283
GO:0007292
GO:0022414
GO:0030983
GO:0043226
GO:0048856
GO:0051321
GO:0140097
GO:0140299
GO:0140657
GO:0140664
HMNXSV003002196
ILMN_1653146
PH_hs_0029108
TC01000778.hg
g4336727_3p_at
Participates
as an input of
Formation of meiotic holliday junction (Homo sapiens)
as an output of
Resolution of meiotic holliday junction (Homo sapiens)
as a component of
MSH4:MSH5 [nucleoplasm] (Homo sapiens)
Cross References
ENSEMBL
ENST00000263187
,
ENSP00000263187
OpenTargets
ENSG00000057468
HPA
ENSG00000057468-MSH4
PRO
O15457
Pharos - Targets
O15457
GlyGen
O15457
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43196 MSH5
1
MSH5 [nucleoplasm]
(R-HSA-912435)
0.635
5
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.581
6
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text