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SPO11 [nucleoplasm]
Stable Identifier
R-HSA-912347
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Meiotic recombination protein SPO11, SPO11_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:double strand break with 3' single strand breaks [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)
SPO11:double strand break with 3' single strand breaks [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:oligonucleotide [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:double strand break with 3' single strand breaks [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)
SPO11:double strand break with 3' single strand breaks [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:oligonucleotide [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11 hydrolyzes DNA forming double-strand breaks (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
SPO11:double stand break [nucleoplasm] (Homo sapiens)
SPO11 Dimer [nucleoplasm] (Homo sapiens)
SPO11 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y5K1 SPO11
Gene Names
SPO11
Chain
chain:1-396
Reference Genes
BioGPS Gene:23626 SPO11
COSMIC (genes):SPO11 SPO11
CTD Gene:23626 SPO11
dbSNP Gene:23626 SPO11
ENSEMBL:ENSG00000054796 SPO11
HGNC:11250 SPO11
KEGG:hsa:23626 SPO11
Monarch:23626 SPO11
NCBI Gene:23626 SPO11
OMIM:605114 SPO11
UCSC:Q9Y5K1 SPO11
Reference Transcript
RefSeq:NM_198265.1 SPO11
RefSeq:NM_012444.2 SPO11
Other Identifiers
11735620_a_at
11735621_x_at
16915134
222259_PM_s_at
222259_s_at
23626
3890524
3890525
3890526
3890527
3890528
3890529
3890530
3890531
3890532
3890534
3890537
3890538
3890539
3890540
3890541
3890542
3890543
3890544
3890545
3890546
8063551
A_14_P103062
A_23_P166027
GE80312
GO:0000228
GO:0000706
GO:0000781
GO:0001541
GO:0003677
GO:0003824
GO:0003916
GO:0003918
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0006259
GO:0006281
GO:0006310
GO:0007129
GO:0007130
GO:0007131
GO:0007141
GO:0007283
GO:0007286
GO:0007292
GO:0016853
GO:0019953
GO:0022414
GO:0034502
GO:0042138
GO:0043226
GO:0045141
GO:0046872
GO:0048477
GO:0048856
GO:0051321
GO:0140013
GO:0140097
GO:0140657
GO:1990918
HMNXSV003042399
HMNXSV003043692
Hs.159737.1.S1_3p_a_at
ILMN_1687970
ILMN_1796655
ILMN_2392747
PH_hs_0029278
TC20000446.hg
Participates
as a component of
SPO11 Dimer [nucleoplasm] (Homo sapiens)
Cross References
ENSEMBL
ENSP00000316034
,
ENST00000345868
,
ENSP00000360310
,
ENST00000371263
,
ENSG00000054796
OpenTargets
ENSG00000054796
IntEnz
5.6.2.2
GeneCards
SPO11
HPA
ENSG00000054796-SPO11
PRO
Q9Y5K1
Pharos - Targets
Q9Y5K1
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